About NBPF family member NBPF12
NBPF family member NBPF12 (NBPF12) is a protein
from Homo sapiens identified by UniProt accession
Q5TAG4, 1457 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | NBPF family member NBPF12 |
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| UniProt accession | Q5TAG4 |
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| Gene | NBPF12 |
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| Organism | Homo sapiens |
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| Length | 1457 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.27
- granulocyte count · score 0.06
- body height · score 0.04
- blood protein measurement · score 0.03
- cancer · score 0.01
- neoplasm · score 0.01
- Thrombocytopenia · score 0.00
- Microcephaly · score 0.00
- Macrocephaly · score 0.00
- triple-negative breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TAG4-F1 | alphafold | PREDICTED | 45.44 | — |
Amino-acid sequence (1457 residues)
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQQLVQ KLSPENDEDE DEDVQVEEDE KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSTV VVDRKSSHDE CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLRPQLA EKKQQFRSLK EKCFVTQLAG FLAKQQNKYK YEECKDLIKS MLRNELQFKE EKLAEQLKQA EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDED EDEDVQVEED EKVLESSSPR EMQKAEESKV PEDSLEECAI TCSNSHGPCD SNQPHKNIKI TFEEDKVNSS LVVDRESSHD ECQDALNILP VPGPTSSATN VSMVVSAGPL SSEKAEMNIL EINEKLRPQL AEKKQQFRSL KEKCFVTQVA CFLAKQQNKY KYEECKDLLK SMLRNELQFK EEKLAEQLKQ AEELRQYKVL VHSQERELTQ LREKLREGRD ASRSLNEHLQ ALLTPDEPDK SQGQDLQEQL AEGCRLAQHL VQKLSPENDN DDDEDVQVEV AEKVQKSSSP REMQKAEEKE VPEDSLEECA ITCSNSHGPY DSNQPHRKTK ITFEEDKVDS TLIGSSSHVE WEDAVHIIPE NESDDEEEEE KGPVSPRNLQ ESEEEEVPQE SWDEGYSTLS IPPERLASYQ SYSSTFHSLE EQQVCMAVDI GRHRWDQVKK EDQEATGPRL SRELLAEKEP EVLQDSLDRC YSTPSVYLGL TDSCQPYRSA FYVLEQQRVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL AEKEPEVLQD SLDRCYSTPS GYLELPDLGQ PYRSAVYSLE EQYLGLALDV DRIKKDQEEE EDQGPPCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ PDSCQPYRSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR RSKKKRRRGR KEGEEDQNPP CPRLSRELLA EKEPEVLQDS LDRWYSTPSV YLGLTDPCQP YRSAFYVLEQ QRVGLAVDMD EIEKYQEVEE DQDPSCPRLS RELLAEKEPE VLQDSLDRCY STPSGYLELP DLGQPYRSAV YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YRSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRSKKKR RRGRKEGEED QNPPCPRLNS VLMEVEEPEV LQDSLDRCYS TPSMYFELPD SFQHYRSVFY SFEEQHITFA LDMDNSFFTL TVTSLHLVFQ MGVIFPQ
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