About U3 small nucleolar RNA-associated protein 14 homolog C
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) is a protein
from Homo sapiens identified by UniProt accession
Q5TAP6, 766 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | U3 small nucleolar RNA-associated protein 14 homolog C |
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| UniProt accession | Q5TAP6 |
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| Gene | UTP14C |
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| Organism | Homo sapiens |
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| Length | 766 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- congenital disorder of glycosylation · score 0.50
- ALG11-congenital disorder of glycosylation · score 0.50
- neurodegenerative disease · score 0.29
- genetic disorder · score 0.15
- azoospermia · score 0.10
- Red cell distribution width · score 0.10
- partial chromosome Y deletion · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failures 50 · score 0.08
- spermatogenic failure 25 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TAP6-F1 | alphafold | PREDICTED | 66.09 | — |
Amino-acid sequence (766 residues)
MNVNQVAENL ALSHQEELVD LPKNYPLSEN EDEGDSDGER KHQKLLEAII SLDGKNRRKL AERSEASLKV SEFSVSSEGS GEKLGLADLL EPVKTSSSLA TVKKQLNRVK SKKVVELPLN KEKIEQIHRE VAFSKTSQVL SKWDPIILKN QQAEQLVFPL GKEQPAIAPI EHALSGWKAR TPLEQEIFNL LHKNKQPVTD PLLTPMEKAS LQAMSLEEAK MHRAELQRAR ALQSYYEAKA RKEKKIKSKK YHKVVKKGKA KKALKEFEQL QKVNPTVALE EMEKIENARM MERMSLKHQN SGKWAKSKAI MAKYDLEARQ AMQEQLAKNK ELTQKLQVAS ESEEEEGGTE VEELLVPHVA NEVQMNVDGP NPWMFRSCTS DTKEAATQED PEQVPELAAH EVSASEAEER PVAEEEILLR EFEERQSLRK RSELNQDAEP ASSQETKDSS SQEVLSELRA LSQKLKEKHQ SRKQKASSEG TVPQVQREEP APEEAEPLLL QRSERVQTLE ELEELGKEDC FQNKELPRPV LEGQQSERTP NNRPDAPKEK KEKEQLINLQ NFLTTQSPSV RSLAVPTIIE ELEDEEERDQ RQMIKEAFAG DDVIRDFLKE KREAVEASKP KDVDLTLPGW GEWGGVGLKP SAKKRRQFLI KAPEGPPRKD KNLPNVIISE KRNIHAAAHQ VQVLPYPFTH HRQFERTIQT PIGSTWNTQR AFQKLTTPKV VTKPGHIIKP IKAEDVGYQS SSRSDLPVIQ RNPKRITTRH NKEEKL
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