Growth hormone-regulated TBC protein 1 (GRTP1)

About Growth hormone-regulated TBC protein 1

Growth hormone-regulated TBC protein 1 (GRTP1) is a protein from Homo sapiens identified by UniProt accession Q5TC63, 336 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Growth hormone-regulated TBC protein 1
UniProt accession	Q5TC63
Gene	GRTP1
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.43
platelet component distribution width · score 0.41
platelet count · score 0.37
C-reactive protein measurement · score 0.27
platelet-to-lymphocyte ratio · score 0.23
intraocular pressure measurement · score 0.11
neutrophil count · score 0.05
high density lipoprotein cholesterol measurement · score 0.05
leukocyte count · score 0.05
blood protein measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TC63-F1	alphafold	PREDICTED	94.68	—

Amino-acid sequence (336 residues)

MQPAERSRVP RIDPYGFERP EDFDDAAYEK FFSSYLVTLT RRAIKWSRLL QGGGVPRSRT VKRYVRKGVP LEHRARVWMV LSGAQAQMDQ NPGYYHQLLQ GERNPRLEDA IRTDLNRTFP DNVKFRKTTD PCLQRTLYNV LLAYGHHNQG VGYCQGMNFI AGYLILITNN EEESFWLLDA LVGRILPDYY SPAMLGLKTD QEVLGELVRA KLPAVGALME RLGVLWTLLV SRWFICLFVD ILPVETVLRI WDCLFNEGSK IIFRVALTLI KQHQELILEA TSVPDICDKF KQITKGSFVM ECHTFMQKIF SEPGSLSMAT VAKLRESCRA RLLAQG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards