Opioid growth factor receptor-like protein 1 (OGFRL1)

About Opioid growth factor receptor-like protein 1

Opioid growth factor receptor-like protein 1 (OGFRL1) is a protein from Homo sapiens identified by UniProt accession Q5TC84, 451 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Opioid growth factor receptor-like protein 1
UniProt accession	Q5TC84
Gene	OGFRL1
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

body height · score 0.34
heel bone mineral density · score 0.30
manic or hypomanic episode · score 0.29
diastolic blood pressure · score 0.28
hypertension · score 0.25
blood phosphate measurement · score 0.22
forced expiratory volume · score 0.10
sitting height measurement · score 0.08
coronary artery disease · score 0.08
stroke · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TC84-F1	alphafold	PREDICTED	70.80	—

Amino-acid sequence (451 residues)

MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEEPGPGGGS EGPGQESEQP AQPPEQAGGR PGASPAPDED AEAAGAEQGG DSTEATAKPK RSFYAARDLY KYRHQYPNFK DIRYQNDLSN LRFYKNKIPF KPDGVYIEEV LSKWKGDYEK LEHNHTYIQW LFPLREQGLN FYAKELTTYE IEEFKKTKEA IRRFLLAYKM MLEFFGIKLT DKTGNVARAV NWQERFQHLN ESQHNYLRIT RILKSLGELG YESFKSPLVK FILHEALVEN TIPNIKQSAL EYFVYTIRDR RERRKLLRFA QKHYTPSENF IWGPPRKEQS EGSKAQKMSS PLASSHNSQT SMHKKAKDSK NSSSAVHLNS KTAEDKKVAP KEPVEETDRP SPEPSNEAAK PRNTEKDSNA ENMNSQPEKT VTTPTEKKES VSPENNEEGG NDNQDNENPG NTNCHDVVLV Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards