About Microtubule cross-linking factor 3
Microtubule cross-linking factor 3 (MTCL3) is a protein
from Homo sapiens identified by UniProt accession
Q5TF21, 947 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Microtubule cross-linking factor 3 |
|---|
| UniProt accession | Q5TF21 |
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| Gene | MTCL3 |
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| Organism | Homo sapiens |
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| Length | 947 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.19
- heel bone mineral density · score 0.18
- bone quantitative ultrasound measurement · score 0.16
- body height · score 0.14
- mathematical ability · score 0.13
- Delayed gross motor development · score 0.12
- Failure to thrive · score 0.12
- Decreased body weight · score 0.12
- Delayed speech and language development · score 0.12
- Hypotonia · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TF21-F1 | alphafold | PREDICTED | 64.33 | — |
Amino-acid sequence (947 residues)
MSQPPIGGAA PATAAASPAA AATEARLHPE GSSRKQQRAQ SPARPRDSSL RQTIAATRSP VGAGTKLNSV RQQQLQQQQQ QGNKTGSRTG PPASIRGGGG GAEKATPLAP KGAAPGAVQP VAGAEAAPAA TLAALGGRRP GPPEEPPREL ESVPSKLGEP PPLGEGGGGG GEGGGAGGGS GEREGGAPQP PPPRGWRGKG VRAQQRGGSG GEGASPSPSS SSAGKTPGTG SRNSGSGVAG GGSGGGGSYW KEGCLQSELI QFHLKKERAA AAAAAAQMHA KNGGGSSSRS SPVSGPPAVC ETLAVASASP MAAAAEGPQQ SAEGSASGGG MQAAAPPSSQ PHPQQLQEQE EMQEEMEKLR EENETLKNEI DELRTEMDEM RDTFFEEDAC QLQEMRHELE RANKNCRILQ YRLRKAERKR LRYAQTGEID GELLRSLEQD LKVAKDVSVR LHHELENVEE KRTTTEDENE KLRQQLIEVE IAKQALQNEL EKMKELSLKR RGSKDLPKSE KKAQQTPTEE DNEDLKCQLQ FVKEEAALMR KKMAKIDKEK DRFEHELQKY RSFYGDLDSP LPKGEAGGPP STREAELKLR LRLVEEEANI LGRKIVELEV ENRGLKAELD DLRGDDFNGS ANPLMREQSE SLSELRQHLQ LVEDETELLR RNVADLEEQN KRITAELNKY KYKSGGHDSA RHHDNAKTEA LQEELKAARL QINELSGKVM QLQYENRVLM SNMQRYDLAS HLGIRGSPRD SDAESDAGKK ESDDDSRPPH RKREGPIGGE SDSEEVRNIR CLTPTRSFYP APGPWPKSFS DRQQMKDIRS EAERLGKTID RLIADTSTII TEARIYVANG DLFGLMDEED DGSRIREHEL LYRINAQMKA FRKELQTFID RLEVPKSADD RGAEEPISVS QMFQPIILLI LILVLFSSLS YTTIFKLVFL FTLFFVL
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