Intermediate filament family orphan 2 (IFFO2)

About Intermediate filament family orphan 2

Intermediate filament family orphan 2 (IFFO2) is a protein from Homo sapiens identified by UniProt accession Q5TF58, 517 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Intermediate filament family orphan 2
UniProt accession	Q5TF58
Gene	IFFO2
Organism	Homo sapiens
Length	517 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

brain measurement · score 0.29
plasminogen activator inhibitor 1 measurement · score 0.13
metabolite measurement · score 0.03
breast carcinoma · score 0.02
dysplasia · score 0.01
nasopharyngeal neoplasm · score 0.00
neoplasm · score 0.00
eosinophilic esophagitis · score 0.00
myeloid sarcoma · score 0.00
liver hemangioma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TF58-F1	alphafold	PREDICTED	68.05	—

Amino-acid sequence (517 residues)

MVNSLLFGEM ALAFGCPPGG GGGGCPGGGG GGGGAGPGPS PVTAALRDDL GSNIHLLKGL NVRFRCFLAK VHELERRNRL LEKQLEQQQS ERERRLRYKT FSREQAVQTG PELLRPPAPG GGHGLSSGAA AGANANAVAL GGLPPGGGSH PQHYGRLPGT IWSYTQVRRT GGGGVETVQG PGVSWVHPDG VGVQIDTITP EIRALYNVLA KVKRERDEYK RRWEEELAKR MNLQTMVDTL QEAAQEADAI QEEMNEKIER LKAELVVFKG LMSDPMTDLD TKIQEKAMKV DMDICRRIDI TAKLCDVAQQ RNSEDVSKIF QVVPKKKERK VASDDDISEQ DGEVNRFSDD EVGSMNITDE MKRMFNQLRE TFDFDDDCDS LTWEENEDTL LLWEDFTNCN PTIDLQGEQE ENLGNLIHET ESFFKTRDKE YQETIGQIEL ELATAKSDMN RHLHEYMEMC SMKRGLDVQM ETCRRLIKGS ADRNSPSPSS VASSDSGSTD EIQDEFEREA DVEPMVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards