About Rho GTPase-activating protein 40
Rho GTPase-activating protein 40 (ARHGAP40) is a protein
from Homo sapiens identified by UniProt accession
Q5TG30, 675 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Rho GTPase-activating protein 40 |
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| UniProt accession | Q5TG30 |
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| Gene | ARHGAP40 |
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| Organism | Homo sapiens |
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| Length | 675 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.33
- metabolite measurement · score 0.04
- esophageal squamous cell carcinoma · score 0.04
- BMI-adjusted leptin measurement · score 0.03
- non-small cell lung carcinoma · score 0.03
- sitting height measurement · score 0.03
- appendicular lean mass · score 0.02
- laryngeal squamous cell carcinoma · score 0.02
- bone density · score 0.02
- urate measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TG30-F1 | alphafold | PREDICTED | 71.87 | — |
Amino-acid sequence (675 residues)
MAEPALLPAA QMERLAPGPL ASPCPRIPRA RIARRCAQRW ADLGCSSGPS SGRMDQLPQK NLLRLHPAGS AGCSTGVESS SMDGFWMEVE QIQQRDELRE EDSGGNEGQL PEEGEAESQW LQDTGLSGLL GGLGLDGDHQ ELLSTLTQTQ VAAVCRRLDI YARSVRRQHK TPVRDVRDVF GVFNSGKMSS ENGDSGMKGA QLSSGASKFP PAAEPGGLQE QAGREEAFNM DSAYSEQAAV LLQRSRPSRG GTSAWGKCSL PKFTVPKGRL GVTRIGDLSL QDMRKVPSLA LIELTALCDI LGLDLKRSKA GKWKAAETRL FGVPLDSLLE ADHKVLPSTQ VPLVLQALLS CLEKRGLDME GILRVPGSQA RVKGLEQKLE RDFYAGLFSW DEVHHNDASD LLKRFIRKLP TPLLTAEYLP AFAVVPNIPN LKQRLQVLHL LILILPEPNR NALKALLEFL RKVVAREQHN KMTLRNVSTV MAPNLFLHQG RPPKLPKGKE KQLAEGAAEV VQIMVHYQDL LWTVASFLVA QVRKLNDSSS RRPQLCDAGL KTWLRRMHAD RDKAGDGLEA TPKVAKIQVV WPIKDPLKVP LTPSTKVAHV LRQFTEHLSP GSKGQEDSED MDSLLLHHRS MESANILLYE VGGNINEHRL DPDAYLLDLY RANPHGEWVL KQNPT
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