PX domain-containing protein 1 (PXDC1)

About PX domain-containing protein 1

PX domain-containing protein 1 (PXDC1) is a protein from Homo sapiens identified by UniProt accession Q5TGL8, 231 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	PX domain-containing protein 1
UniProt accession	Q5TGL8
Gene	PXDC1
Organism	Homo sapiens
Length	231 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.28
optic cup area measurement · score 0.17
clavicle fracture · score 0.12
Barrett's esophagus · score 0.09
Esophagitis · score 0.09
metabolite measurement · score 0.09
Blackfan-Diamond anemia · score 0.09
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
adolescent idiopathic scoliosis · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TGL8-F1	alphafold	PREDICTED	69.55	—

Amino-acid sequence (231 residues)

MASAVFEGTS LVNMFVRGCW VNGIRRLIVS RRGDEEEFFE IRTEWSDRSV LYLHRSLADL GRLWQRLRDA FPEDRSELAQ GPLRQGLVAI KEAHDIETRL NEVEKLLKTI ISMPCKYSRS EVVLTFFERS PLDQVLKNDN VHKIQPSFQS PVKISEIMRS NGFCLANTET IVIDHSIPNG RDQQLGVDPT EHLFENGSEF PSELEDGDDP AAYVTNLSYY HLVPFETDIW D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards