About Brefeldin A-inhibited guanine nucleotide-exchange protein 3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF3) is a protein
from Homo sapiens identified by UniProt accession
Q5TH69, 2177 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 |
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| UniProt accession | Q5TH69 |
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| Gene | ARFGEF3 |
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| Organism | Homo sapiens |
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| Length | 2177 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (118)
Diseases linked to this target (Open Targets).
- early-onset generalized dystonia · score 0.37
- dystonic disorder · score 0.12
- Dystonia · score 0.12
- Febrile seizure (within the age range of 3 months to 6 years) · score 0.12
- MODY · score 0.08
- osteosarcoma · score 0.07
- rheumatoid arthritis · score 0.07
- hyperinsulinism due to glucokinase deficiency · score 0.06
- hyperinsulinism due to INSR deficiency · score 0.06
- drug use measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TH69-F1 | alphafold | PREDICTED | 64.81 | — |
Amino-acid sequence (2177 residues)
MEEILRKLQK EASGSKYKAI KESCTWALET LGGLDTIVKI PPHVLREKCL LPLQLALESK NVKLAQHALA GMQKLLSEER FVSMETDSDE KQLLNQILNA VKVTPSLNED LQVEVMKVLL CITYTPTFDL NGSAVLKIAE VCIETYISSC HQRSINTAVR ATLSQMLSDL TLQLRQRQEN TIIENPDVPQ DFGNQGSTVE SLCDDVVSVL TVLCEKLQAA INDSQQLQLL YLECILSVLS SSSSSMHLHR RFTDLIWKNL CPALIVILGN PIHDKTITSA HTSSTSTSLE SDSASPGVSD HGRGSGCSCT APALSGPVAR TIYYIAAELV RLVGSVDSMK PVLQSLYHRV LLYPPPQHRV EAIKIMKEIL GSPQRLCDLA GPSSTESESR KRSISKRKSH LDLLKLIMDG MTEACIKGGI EACYAAVSCV CTLLGALDEL SQGKGLSEGQ VQLLLLRLEE LKDGAEWSRD SMEINEADFR WQRRVLSSEH TPWESGNERS LDISISVTTD TGQTTLEGEL GQTTPEDHSG NHKNSLKSPA IPEGKETLSK VLETEAVDQP DVVQRSHTVP YPDITNFLSV DCRTRSYGSR YSESNFSVDD QDLSRTEFDS CDQYSMAAEK DSGRSDVSDI GSDNCSLADE EQTPRDCLGH RSLRTAALSL KLLKNQEADQ HSARLFIQSL EGLLPRLLSL SNVEEVDTAL QNFASTFCSG MMHSPGFDGN SSLSFQMLMN ADSLYTAAHC ALLLNLKLSH GDYYRKRPTL APGVMKDFMK QVQTSGVLMV FSQAWIEELY HQVLDRNMLG EAGYWGSPED NSLPLITMLT DIDGLESSAI GGQLMASAAT ESPFAQSRRI DDSTVAGVAF ARYILVGCWK NLIDTLSTPL TGRMAGSSKG LAFILGAEGI KEQNQKERDA ICMSLDGLRK AARLSCALGV AANCASALAQ MAAASCVQEE KEEREAQEPS DAITQVKLKV EQKLEQIGKV QGVWLHTAHV LCMEAILSVG LEMGSHNPDC WPHVFRVCEY VGTLEHNHFS DGASQPPLTI SQPQKATGSA GLLGDPECEG SPPEHSPEQG RSLSTAPVVQ PLSIQDLVRE GSRGRASDFR GGSLMSGSSA AKVVLTLSTQ ADRLFEDATD KLNLMALGGF LYQLKKASQS QLFHSVTDTV DYSLAMPGEV KSTQDRKSAL HLFRLGNAML RIVRSKARPL LHVMRCWSLV APHLVEAACH KERHVSQKAV SFIHDILTEV LTDWNEPPHF HFNEALFRPF ERIMQLELCD EDVQDQVVTS IGELVEVCST QIQSGWRPLF SALETVHGGN KSEMKEYLVG DYSMGKGQAP VFDVFEAFLN TDNIQVFANA ATSYIMCLMK FVKGLGEVDC KEIGDCAPAP GAPSTDLCLP ALDYLRRCSQ LLAKIYKMPL KPIFLSGRLA GLPRRLQEQS ASSEDGIESV LSDFDDDTGL IEVWIILLEQ LTAAVSNCPR QHQPPTLDLL FELLRDVTKT PGPGFGIYAV VHLLLPVMSV WLRRSHKDHS YWDMASANFK HAIGLSCELV VEHIQSFLHS DIRYESMINT MLKDLFELLV ACVAKPTETI SRVGCSCIRY VLVTAGPVFT EEMWRLACCA LQDAFSATLK PVKDLLGCFH SGTESFSGEG CQVRVAAPSS SPSAEAEYWR IRAMAQQVFM LDTQCSPKTP NNFDHAQSCQ LIIELPPDEK PNGHTKKSVS FREIVVSLLS HQVLLQNLYD ILLEEFVKGP SPGEEKTIQV PEAKLAGFLR YISMQNLAVI FDLLLDSYRT AREFDTSPGL KCLLKKVSGI GGAANLYRQS AMSFNIYFHA LVCAVLTNQE TITAEQVKKV LFEDDERSTD SSQQCSSEDE DIFEETAQVS PPRGKEKRQW RARMPLLSVQ PVSNADWVWL VKRLHKLCME LCNNYIQMHL DLENCMEEPP IFKGDPFFIL PSFQSESSTP STGGFSGKET PSEDDRSQSR EHMGESLSLK AGGGDLLLPP SPKVEKKDPS RKKEWWENAG NKIYTMAADK TISKLMTEYK KRKQQHNLSA FPKEVKVEKK GEPLGPRGQD SPLLQRPQHL MDQGQMRHSF SAGPELLRQD KRPRSGSTGS SLSVSVRDAE AQIQAWTNMV LTVLNQIQIL PDQTFTALQP AVFPCISQLT CHVTDIRVRQ AVREWLGRVG RVYDIIV
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