About Protein PRR14L
Protein PRR14L (PRR14L) is a protein
from Homo sapiens identified by UniProt accession
Q5THK1, 2151 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Protein PRR14L |
|---|
| UniProt accession | Q5THK1 |
|---|
| Gene | PRR14L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 2151 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.20
- IGF-1 measurement · score 0.13
- insulin like growth factor measurement · score 0.11
- reticulocyte count · score 0.07
- lymphocyte count · score 0.05
- mathematical ability · score 0.04
- diastolic blood pressure · score 0.04
- Chest pain · score 0.02
- myeloid neoplasm · score 0.02
- body height · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5THK1-F1 | alphafold | PREDICTED | 35.51 | — |
Amino-acid sequence (2151 residues)
MLSSGVETQP VPLDSSMSAV VQELYSELPV SVSRELHADP EPSVIPDVKP GASSSLLSQN RALPLELQRT HVESCCEETY ETLDHGSEPG RCGLVDSTAG GSVASGILDR AKRSESMEPK VFRDPGGQAG IIREPSEGAK EDPHQHSTAA EEKTSPSQED LLMQSSKELS HVDLPEDFLR SKEGNVQITA ETLLKSAEVQ GMKVNGTKTD NNEGHKNGNV SKDLSAGCGE FQEVDKIMTS DEVSETSTLV TPEPLTFVDP VLTEATPKEK ECEELKSCPW LSLPGNSAIS NVDNGKEELC KPNLVCEADD NHQQLHGHHN EQPSSTHDSP TATSPLKENS EVSCFTSDLS GPESRTISLE NCGFEGGGLL KRSAEKTDSS YFYRGDDQGK NLASREENEE RLLIPRSERG GPFLFNAREP EKEISGRCSG EKEPVVSPKE NIHNNCIQDS LHTGNSSSLM PNSFTEATEV MLNKNDLKIT VHVQGNLTNP EDHKETFTNM SHPGGHSEES SFSSLMQIEE AGQTTPVEPN ILSKSFYTKD CNSLVSIQRN LEGNTQLNEA SCNDFLFERK SIVSLMPEDQ ISPVSEVLKP KQGTALLLPS PEFDYRPESE KVIQTSHDDI PLLDEQSIAC EMNELSCTNE LVVNKVESEC VLNQQVSLNS QEHANLPTDS LLHLNKEMPL ATGRDAHQSH HPPLEGRADV IADIQTIPIQ TKIKDISPPG NQTCGASSNC PTLNIKPVSL ERKKEMADSG TKALHSRLRS NKREAAGFPQ VVSVIECHSV QSQDISSCHR VRKNVSQENM CSASAAFKSS KISLQVDNSL ITKYENAFQH RDHCCQGTGH SVEKSSCKVS YTSQERELDG KETNGSLPGD KIRNKMVAGL LNSGISNKTI HTSSSIKLSE EGLEGKEQDV SKETVFCKYN ISDHAIQELN QTVNIPGPEK VLDQSPTVMF SSFKNVKSVE TLDQKADEVL DCQSNQNRPD ECKSEGQSAK EMLSSDQRET VTEPHGEVNH NQKDLLVSSG SNNSLPCGSP KKCNLKGAFV KMSGCDESTE GMVDIVYTDC SNKLAEGVLD VKASNLLDCG ARQEKLAFQE DSRSTLSRRE LDAAHTGTTG QDSDFPVTAA STVDFLKIKK SCEENVCRSL KDCEMEKCPD SCAHEMESVA DHEPNKRILG RVNLSLNDSH YGQQDKGTSL RETQEMTEGS RLEPNSEFGK ESTFGISSKE SMSCHDESSV SLRSLKSIEI MPSQENSETN VNSEETDLKN LCKPKDGEML CENVKDCTVL PEMKEIVSRD WSNSSDRDSV CTCVEKNACK ACHPHENSSD RHLPLTVKTD IKVKGEETEE HQRGRLGYLT VGEQSEELVT RETGDGDPVS NISQTHFKCR GILNHAEKQQ SPEVLDYMLQ KEEKYIRQQK AHTISQQCIS SSLLLDDAQN QNQPKADKDE STMINEITLA KLAKDSIVAQ TQKLEDQKEE RLHHPLRKDT ESCTSPCLLG APRKAQDPSS AGCDQIHGAF AKKGVLPLKK QPHRTCKKVS YQEQIIVGRK IGKIRSSAFL KSSSNPIPTK AHRLLSLCTL SAPTRLEPET APTKSLVSHI PKQMSTPCHP LRSLNFRKTT KESALLNKLS ILASKLAPAM KTQKLRYRRC SSELLPMAKS YKRLRYKRLL DGFSSSTEQL NPYLAASGWD KRPNSKPMAL YSLESIKMTF IDLSNKMPSL LFGSEIFPVS FHVKSSSSDC TTESSRTFPE HCAPARLALG EALQCPSQPP KWTFSFFLSH GCPGMATFRE DTGVHSQTHT QAPPQPPAPL QDYGGTAIVQ TRADCSVLGL HTLLALCSPG CYRIWTKKRS FSSHMPTMQR LFMTQFTQGL KGLRSPASIA DKVFCSLPYS VGRVLSIWSQ HGPSVCSFEI SSLHSPHCKR QPSLGTTSSH TMLPYVPLPG MEATYNTSGS QTRLEPPFPA LVPKSCLVAE SAVSKLLLSA SEFQVRGLDE LDGVKAACPC PQSSPPEQKE AEPEKRPKKV SQIRIRKTIP RPDPNLTPMG LPRPKRLKKK EFSLEEIYTN KNYKSPPANR CLETIFEEPK ERNGTLISIS QQKRKRVLEF QDFTVPRKRR ARGKVKVAGS FTRAQKAAVQ SRELDALLIQ KLMELETFFA KEEEQEQSSG C
Explore Protein PRR14L with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets