About EF-hand calcium-binding domain-containing protein 6
EF-hand calcium-binding domain-containing protein 6 (EFCAB6) is a protein
from Homo sapiens identified by UniProt accession
Q5THR3, 1501 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 6 |
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| UniProt accession | Q5THR3 |
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| Gene | EFCAB6 |
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| Organism | Homo sapiens |
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| Length | 1501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.31
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- sleep measurement · score 0.10
- IGF-1 measurement · score 0.07
- drug use measurement · score 0.06
- self reported educational attainment · score 0.06
- triglyceride measurement · score 0.03
- diacylglycerol 38:5 measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5THR3-F1 | alphafold | PREDICTED | 68.92 | — |
Amino-acid sequence (1501 residues)
MCKMAIIPDW LRSHPHTRKF THSRPHSSPC RVYSRNGSPN KFRSSSTTAV ANPTLSSLDV KRILFQKITD RGDELQKAFQ LLDTGQNLTV SKSELRRIIT DFLMPLTREQ FQDVLAQIPL STSGTVPYLA FLSRFGGIDL YINGIKRGGG NEMNCCRTLR ELEIQVGEKV FKNIKTVMKA FELIDVNKTG LVRPQELRRV LETFCMKLRD EEYEKFSKHY NIHKDTAVDY NVFLKNLSIN NDLNLRYCMG NQEVSLENQQ AKNSKKERLL GSASSEDIWR NYSLDEIERN FCLQLSKSYE KVEKALSAGD PCKGGYVSFN YLKIVLDTFV YQIPRRIFIQ LMKRFGLKAT TKINWKQFLT SFHEPQGLQV SSKGPLTKRN SINSRNESHK ENIITKLFRH TEDHSASLKK ALLIINTKPD GPITREEFRY ILNCMAVKLS DSEFKELMQM LDPGDTGVVN TSMFIDLIEE NCRMRKTSPC TDAKTPFLLA WDSVEEIVHD TITRNLQAFY NMLRSYDLGD TGRIGRNNFK KIMHVFCPFL TNAHFIKLCS KIQDIGSGRI LYKKLLACIG IDGPPTVSPV LVPKDQLLSE HLQKDEQQQP DLSERTKLTE DKTTLTKKMT TEEVIEKFKK CIQQQDPAFK KRFLDFSKEP NGKINVHDFK KVLEDTGMPM DDDQYALLTT KIGFEKEGMS YLDFAAGFED PPMRGPETTP PQPPTPSKSY VNSHFITAEE CLKLFPRRLK ESFRDPYSAF FKTDADRDGI INMHDLHRLL LHLLLNLKDD EFERFLGLLG LRLSVTLNFR EFQNLCEKRP WRTDEAPQRL IRPKQKVADS ELACEQAHQY LVTKAKNRWS DLSKNFLETD NEGNGILRRR DIKNALYGFD IPLTPREFEK LWARYDTEGK GHITYQEFLQ KLGINYSPAV HRPCAEDYFN FMGHFTKPQQ LQEEMKELQQ STEKAVAARD KLMDRHQDIS KAFTKTDQSK TNYISICKMQ EVLEECGCSL TEGELTHLLN SWGVSRHDNA INYLDFLRAV ENSKSTGAQP KEKEESMPIN FATLNPQEAV RKIQEVVESS QLALSTAFSA LDKEDTGFVK ATEFGQVLKD FCYKLTDNQY HYFLRKLRIH LTPYINWKYF LQNFSCFLEE TADEWAEKMP KGPPPTSPKA TADRDILARL HKAVTSHYHA ITQEFENFDT MKTNTISREE FRAICNRRVQ ILTDEQFDRL WNEMPVNAKG RLKYPDFLSR FSSETAATPM ATGDSAVAQR GSSVPDVSEG TRSALSLPTQ ELRPGSKSQS HPCTPASTTV IPGTPPLQNC DPIESRLRKR IQGCWRQLLK ECKEKDVARQ GDINASDFLA LVEKFNLDIS KEECQQLIIK YDLKSNGKFA YCDFIQSCVL LLKAKESSLM HRMKIQNAHK MKEAGAETPS FYSALLRIQP KIVHCWRPMR RTFKSYDEAG TGLLSVADFR TVLRQYSINL SEEEFFHILE YYDKTLSSKI SYNDFLRAFL Q
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