About Zinc finger protein 658
Zinc finger protein 658 (ZNF658) is a protein
from Homo sapiens identified by UniProt accession
Q5TYW1, 1059 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | Zinc finger protein 658 |
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| UniProt accession | Q5TYW1 |
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| Gene | ZNF658 |
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| Organism | Homo sapiens |
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| Length | 1059 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (8)
Diseases linked to this target (Open Targets).
- pancreatic adenocarcinoma · score 0.14
- MODY · score 0.06
- hyperproinsulinemia · score 0.04
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.04
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
- diabetes mellitus, permanent neonatal 4 · score 0.04
- diabetes mellitus, transient neonatal, 3 · score 0.03
- permanent neonatal diabetes mellitus 1 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TYW1-F1 | alphafold | PREDICTED | 60.20 | — |
Amino-acid sequence (1059 residues)
MNMSQASVSF QDVTVEFTRE EWQHLGPVER TLYRDVMLEN YSHLISVGYC ITKPKVISKL EKGEEPWSLE DEFLNQRYPG YFKVDHIKGI REKQEKPLWQ EIFISDADKT LSKEGQKVLE KPFNLEIAPE LSEKISCKCD SHRMNLPVAS QLIISERKYS RKKTEYMNVC EKLQLDIKHE KAHAEEKSYE HGENAKAFSY KKDQHWKFQT LEESFECDGS GQGLYDKTIC ITPQSFLTGE KSCKDDEFRK NFDKITLFNH MRTDTRGKCS DLNEYGTSCD KTTAVEYNKV HMAMTHYECN ERGINFSRKS PLTQSQRTIT GWSAFESNKC EENFSQSSAH IVHQKTQAGD KFGEHNECTD ALYQKLDFTA HQRIHTEDKF YLSDEHGKCR KSFYRKAHLI QHQRPHSGEK TYQYEECAKS FCSSSHPIQH PGTYVGFKLY ECNECGKAFC QNSNLSKHLR IHTKEKPCDN NGCGRSYKSP LIGHQKTDAE MELCGGSEYG KTSHLKGHQR ILMGEKPYEC IECGKTFSKT SHLRAHQRIH TGEKPYECVE CEKTFSHKTH LSVHQRVHTG EKPYECNDCG KSFTYNSALR AHQRIHTGEK PYECSDCEKT FAHNSALRAH HRIHTGEKPY ECNECGRSFA HISVLKAHQR IHTGEKPYEC NECGRSFTYN SALRAHQRIH TGRKPYECSD CEKTFAHNSA LKIHQRIHTG EKPYECNECE KTFAHNSALR AHQNIHTGEK LYECSECGKT FFQKTRLSTH RRIHTGEKPY ECSKCGKTFS QKSYLSGHER IHTGEKPYEC NVCGKTFVYK AALIVHQRIH TGEKPYECNQ CGKTFSQRTH LCAHQRIHTG EKPYECNECG KTFADNSALR AHHRIHTGEK PYECNDCGKT FSKTSHLRAH LRTRSGEKPY ECSECGKTFS EKSYVSAHQR VHTGEKPYEC NVCGKPFAHN STLRVHQRIH TGEKSYECND CGKTFSQKSH LSAHQRIHTG EKPYECNECG KAFAQNSTLR VHQRIHTGEK PYECDECGKT FVRKAALRVH HTRMHTREKT LACNGFGKS
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