About Aspartate beta-hydroxylase domain-containing protein 1
Aspartate beta-hydroxylase domain-containing protein 1 (ASPHD1) is a protein
from Homo sapiens identified by UniProt accession
Q5U4P2, 390 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Aspartate beta-hydroxylase domain-containing protein 1 |
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| UniProt accession | Q5U4P2 |
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| Gene | ASPHD1 |
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| Organism | Homo sapiens |
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| Length | 390 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.20
- body fat percentage · score 0.18
- sodium measurement · score 0.15
- aspartate aminotransferase measurement · score 0.12
- sex hormone-binding globulin measurement · score 0.12
- high density lipoprotein cholesterol measurement · score 0.12
- serum alanine aminotransferase measurement · score 0.12
- low density lipoprotein triglyceride measurement · score 0.12
- body mass index · score 0.09
- schizophrenia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5U4P2-F1 | alphafold | PREDICTED | 74.31 | — |
Amino-acid sequence (390 residues)
MKEGRGSFSV ERGPRKERET AQSGMWKGNS PAGSQGAAME GTGGELGGQG NWGPEDAPGL LARASLIMLP WPLPLASSAL TLLFGALTSL FLWYCYRLGS QDMQALGAGS RAGGVRGGPV GCSEAGGPSP GGPGDPGEGP RTEGLVSRRL RAYARRYSWA GMGRVRRAAQ GGPGPGRGPG VLGIQRPGLL FLPDLPSAPF VPRDAQRHDV ELLESSFPAI LRDFGAVSWD FSGTTPPPRG WSPPLAPGCY QLLLYQAGRC QPSNCRRCPG AYRALRGLRS FMSANTFGNA GFSVLLPGAR LEGRCGPTNA RVRCHLGLKI PPGCELVVGG EPQCWAEGHC LLVDDSFLHT VAHNGSPEDG PRVVFIVDLW HPNVAGAERQ ALDFVFAPDP
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