About Activating transcription factor 7-interacting protein 2
Activating transcription factor 7-interacting protein 2 (ATF7IP2) is a protein
from Homo sapiens identified by UniProt accession
Q5U623, 682 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Activating transcription factor 7-interacting protein 2 |
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| UniProt accession | Q5U623 |
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| Gene | ATF7IP2 |
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| Organism | Homo sapiens |
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| Length | 682 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- IGF-1 measurement · score 0.42
- wet macular degeneration · score 0.30
- disease progression measurement · score 0.30
- insulin like growth factor measurement · score 0.27
- 3-hydroxypropylmercapturic acid measurement · score 0.12
- schizophrenia · score 0.08
- bipolar disorder · score 0.08
- obsessive-compulsive disorder · score 0.05
- attention deficit hyperactivity disorder · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5U623-F1 | alphafold | PREDICTED | 55.91 | — |
Amino-acid sequence (682 residues)
MASPDRSKRK ILKAKKTMPL SCRKQVEMLN KSRNVEALKT AIGSNVPSGN QSFSPSVITR TTEITKCSPS ENGASSLDSN KNSISEKSKV FSQNCIKPVE EIVHSETKLE QVVCSYQKPS RTTESPSRVF TEEAKDSLNT SENDSEHQTN VTRSLFEHEG ACSLKSSCCP PSVLSGVVQM PESTVTSTVG DKKTDQMVFH LETNSNSESH DKRQSDNILC SEDSGFVPVE KTPNLVNSVT SNNCADDILK TDECSRTSIS NCESADSTWQ SSLDTNNNSH YQKKRMFSEN EENVKRMKTS EQINENICVS LERQTAFLEQ VRHLIQQEIY SINYELFDKK LKELNQRIGK TECRNKHEGI ADKLLAKIAK LQRRIKTVLL FQRNCLKPNM LSSNGASKVA NSEAMILDKN LESVNSPIEK SSVNYEPSNP SEKGSKKINL SSDQNKSVSE SNNDDVMLIS VESPNLTTPI TSNPTDTRKI TSGNSSNSPN AEVMAVQKKL DSIIDLTKEG LSNCNTESPV SPLESHSKAA SNSKETTPLA QNAVQVPESF EHLPPLPEPP APLPELVDKT RDTLPPQKPE LKVKRVFRPN GIALTWNITK INPKCAPVES YHLFLCHENS NNKLIWKKIG EIKALPLPMA CTLSQFLASN RYYFTVQSKD IFGRYGPFCD IKSIPGFSEN LT
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