G-protein coupled receptor 157 (GPR157)

About G-protein coupled receptor 157

G-protein coupled receptor 157 (GPR157) is a protein from Homo sapiens identified by UniProt accession Q5UAW9, 335 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	G-protein coupled receptor 157
UniProt accession	Q5UAW9
Gene	GPR157
Organism	Homo sapiens
Length	335 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

leukocyte count · score 0.39
monocyte percentage of leukocytes · score 0.37
aspartate aminotransferase measurement · score 0.36
monocyte count · score 0.35
neurofibrillary tangles measurement · score 0.30
eye color · score 0.29
FEV/FVC ratio · score 0.28
granulocyte percentage of myeloid white cells · score 0.27
insulin like growth factor measurement · score 0.27
lymphocyte:monocyte ratio · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5UAW9-F1	alphafold	PREDICTED	81.38	—

Amino-acid sequence (335 residues)

MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL LFLSLADLLS AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI ALYLYLSIVR AARGPRTDRL LWAFHVVSWG VPLVITVAAV ALKKIGYDAS DVSVGWCWID LEAKDHVLWM LLTGKLWEML AYVLLPLLYL LVRKHINRAH TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW STVRFVLTLC GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards