ER membrane protein complex subunit 10 (EMC10)

About ER membrane protein complex subunit 10

ER membrane protein complex subunit 10 (EMC10) is a protein from Homo sapiens identified by UniProt accession Q5UCC4, 262 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	ER membrane protein complex subunit 10
UniProt accession	Q5UCC4
Gene	EMC10
Organism	Homo sapiens
Length	262 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with dysmorphic facies and variable seizures · score 0.67
Neurodevelopmental disorder · score 0.37
complex neurodevelopmental disorder · score 0.37
genetic disorder · score 0.19
hematocrit · score 0.18
hemoglobin measurement · score 0.16
erythrocyte count · score 0.15
red blood cell density measurement · score 0.12
Intellectual disability · score 0.12
azoospermia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5UCC4-F1	alphafold	PREDICTED	77.54	—

Amino-acid sequence (262 residues)

MAAASAGATR LLLLLLMAVA APSRARGSGC RAGTGARGAG AEGREGEACG TVGLLLEHSF EIDDSANFRK RGSLLWNQQD GTLSLSQRQL SEEERGRLRD VAALNGLYRV RIPRRPGALD GLEAGGYVSS FVPACSLVES HLSDQLTLHV DVAGNVVGVS VVTHPGGCRG HEVEDVDLEL FNTSVQLQPP TTAPGPETAA FIERLEMEQA QKAKNPQEQK SFFAKYWMYI IPVVLFLMMS GAPDTGGQGG GGGGGGGGGS GR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards