About Phosphoinositide 3-kinase regulatory subunit 6
Phosphoinositide 3-kinase regulatory subunit 6 (PIK3R6) is a protein
from Homo sapiens identified by UniProt accession
Q5UE93, 754 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Phosphoinositide 3-kinase regulatory subunit 6 |
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| UniProt accession | Q5UE93 |
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| Gene | PIK3R6 |
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| Organism | Homo sapiens |
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| Length | 754 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.28
- eosinophil percentage of leukocytes · score 0.22
- eosinophil count · score 0.19
- neutrophil immunodeficiency syndrome · score 0.07
- Blackfan-Diamond anemia · score 0.06
- X-linked severe congenital neutropenia · score 0.06
- myeloperoxidase deficiency · score 0.05
- neutropenia, severe congenital, 2, autosomal dominant · score 0.05
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency · score 0.05
- nonimmune chronic idiopathic neutropenia of adults · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5UE93-F1 | alphafold | PREDICTED | 74.34 | — |
Amino-acid sequence (754 residues)
MESSDVELDL QRSVQAVLRE LSTQAPALQS NQGMWRWSLH KKVERDPGKS PVLVRILLRE LEKAESQDLR HVIIPLLHTV MYVLTKATGI TEELYQRIYA FCTRLLTLPT PYCTVALDCA IRLKTEMAVP GTLYQRMVIA EQNLTNELYP YQERVFLFVD PELVSASVCS ALLLEIEAAQ AQQTPETCMR HVVSHALQAA LGEACHAGAL HRKLQASPRR TLEHYFHAVV AALEQMASEA SPSREGHVER LEEIYCSLLG PAAGRCGGDL VQERPPSIPL PSPYITFHLW TGEEQLWKEL VLFLRPRSQL RLSADLEVLD LQGLRPDREL ARVSVLSTDS GIERDLPTGA DELPAPGSPE MERAGLQRKG GIKKRAWPLD FLMPGSWDGP PGLHRRTGRP SGDGEMLPGV SRLHTARVLV LGDDRMLGRL AQAYHRLRKR ETQKFCLTPR LSLQLYYIPV LAPEKPAASR QPELGELATF LGRVDPWYQS NVNTLCPAIH KLAEMPPSLD TSRTVDPFIL DVITYYIRMG TQPIYFQIYT VKIFFSDLSQ DPTEDIFLIE LKVKIQDSKF PKDGFSPRRR GVAEGPGAEL SLCYQKALLS HRPREVTVSL RATGLILKAI PASDTEVSGS SHCPLPAAPV TDHTCLNVNV TEVVKSSNLA GKSFSTVTNT FRTNNIQIQS RDQRLLTLSL DKDDQRTFRD VVRFEVAPCP EPCSGAQKSK APWLNLHGQQ EVEAIKAKPK PLLMPINTFS GIVQ
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