About Vacuolar protein sorting-associated protein 53 homolog
Vacuolar protein sorting-associated protein 53 homolog (VPS53) is a protein
from Homo sapiens identified by UniProt accession
Q5VIR6, 832 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 53 homolog |
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| UniProt accession | Q5VIR6 |
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| Gene | VPS53 |
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| Organism | Homo sapiens |
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| Length | 832 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 2E · score 0.70
- pontocerebellar hypoplasia · score 0.53
- neurodegenerative disease · score 0.53
- Non-syndromic pontocerebellar hypoplasia · score 0.47
- progressive cerebello-cerebral atrophy · score 0.46
- Global developmental delay · score 0.37
- Intellectual disability · score 0.37
- prostate carcinoma · score 0.33
- BMI-adjusted waist circumference · score 0.32
- high density lipoprotein cholesterol measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VIR6-F1 | alphafold | PREDICTED | 80.21 | — |
Amino-acid sequence (832 residues)
MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDRA DFNAVEYINT LFPTEQSLAN IDEVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQALEEA QKAIQQLFGK IKDIKDKAEK SEQMVKEITR DIKQLDHAKR HLTTSITTLN HLHMLAGGVD SLEAMTRRRQ YGEVANLLQG VMNVLEHFHK YMGIPQIRQL SERVKAAQTE LGQQILADFE EAFPSQGTKR PGGPSNVLRD ACLVANILDP RIKQEIIKKF IKQHLSEYLV LFQENQDVAW LDKIDRRYAW IKRQLVDYEE KYGRMFPREW CMAERIAVEF CHVTRAELAK IMRTRAKEIE VKLLLFAIQR TTNFEGFLAK RFSGCTLTDG TLKKLESPPP STNPFLEDEP TPEMEELATE KGDLDQPKKP KAPDNPFHGI VSKCFEPHLY VYIESQDKNL GELIDRFVAD FKAQGPPKPN TDEGGAVLPS CADLFVYYKK CMVQCSQLST GEPMIALTTI FQKYLREYAW KILSGNLPKT TTSSGGLTIS SLLKEKEGSE VAKFTLEELC LICNILSTAE YCLATTQQLE EKLKEKVDVS LIERINLTGE MDTFSTVISS SIQLLVQDLD AACDPALTAM SKMQWQNVEH VGDQSPYVTS VILHIKQNVP IIRDNLASTR KYFTQFCVKF ANSFIPKFIT HLFKCKPISM VGAEQLLLDT HSLKMVLLDL PSISSQVVRK APASYTKIVV KGMTRAEMIL KVVMAPHEPL VVFVDNYIKL LTDCNTETFQ KILDMKGLKR SEQSSMLELL RQRLPAPPSG AESSGSLSLT APTPEQESSR IRKLEKLIKK RL
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