About NUT family member 2D
NUT family member 2D (NUTM2D) is a protein
from Homo sapiens identified by UniProt accession
Q5VT03, 806 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | NUT family member 2D |
|---|
| UniProt accession | Q5VT03 |
|---|
| Gene | NUTM2D |
|---|
| Organism | Homo sapiens |
|---|
| Length | 806 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.23
- cutaneous melanoma · score 0.18
- breast carcinoma · score 0.18
- oral squamous cell carcinoma · score 0.18
- acute myeloid leukemia · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- hepatocellular carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- colorectal adenocarcinoma · score 0.18
- B-cell acute lymphoblastic leukemia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VT03-F1 | alphafold | PREDICTED | 47.17 | — |
Amino-acid sequence (806 residues)
MFQEPVYFQI FLFQLDSGAS GEPGHSLGLT LGFSHCGNCQ TAVVSAQPEG MASNGAYPAL GPGVTANPGT SLSVFTALPF TTPAPGPAHG PLLVTAGAPP GGPLVLSNFP STPLVTEQDG CGPSGAGASN VFVQMRTEVG PVKAAQAQTL VLTQTPLVWQ APGALCGGVV CPPPLLLAAA PVVPVMAAQV VGGTQACEGG WSQGLPLPPP PPPAAQLPPI VSQGNAGPWP QGAHGEGSLA SSQAKAPPDD SCNPRSVYEN FRLWQHYKPL ARRHLPQSPD TEALSCFLIP VLRSLARRKP TMTLEEGLWR AMREWQHTSN FDRMIFYEMA EKFLEFEAEE EMQIQKSQWM KGPQCLPPPA TPRLEPRGPP APEVVKQPVY LPSKAGPKAP TACLPPPRPQ RPVTKARRPP PRPHRRAETK ARLPPPRPQR PAETKVPEEI PPEVVQEYVD IMEELLGPSL GATGEPEKQR EEGEVKQPQE EDWTPPDPGL LSYTDKLCSQ KDFVTKVEAV IHPQFLEELL SPDPQMDFLA LSQELEQEEG LTLAQLVEKR LLPLKEKQHA RAAPSRGTAR LDSSSSKFAA GQGAERDVPD PQQGVGMETC PPQTTARDSQ GRGRAHTGMA RSKDSVVLLG CQDSPGLRAA RPTSPPQDHR PTCPGVGTKD ALDLPGGSPV RESHGLAQGS SEEEELPSLA FLLGSQHKLL PWWLPQSPVP ASGLLSPEKW GPQGTHQSPS AERRGLNLAP SPANKAKKRP LFGSLSPAEK TPHPGPGLRV SGEQSLTWGL GGPSQSQKRK GDPLVSRKEK KQRCSQ
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