About Regulation of nuclear pre-mRNA domain-containing protein 2
Regulation of nuclear pre-mRNA domain-containing protein 2 (RPRD2) is a protein
from Homo sapiens identified by UniProt accession
Q5VT52, 1461 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Regulation of nuclear pre-mRNA domain-containing protein 2 |
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| UniProt accession | Q5VT52 |
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| Gene | RPRD2 |
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| Organism | Homo sapiens |
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| Length | 1461 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (88)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.24
- blood protein measurement · score 0.21
- chronotype measurement · score 0.20
- platelet count · score 0.19
- protein measurement · score 0.18
- schizophrenia · score 0.17
- platelet crit · score 0.16
- body fat percentage · score 0.15
- Red cell distribution width · score 0.14
- osteoarthritis · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VT52-F1 | alphafold | PREDICTED | 47.53 | — |
Amino-acid sequence (1461 residues)
MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE NKKHHSTIVY HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF ADVLPEAAAL VKDPSVSKSV ERIFKIWEDR NVYPEEMIVA LREALSTTFK TQKQLKENLN KQPNKQWKKS QTSTNPKAAL KSKIVAEFRS QALIEELLLY KRSEDQIELK EKQLSTMRVD VCSTETLKCL KDKTGGKKFS KEFEEASSKL EEFVNGLDKQ VKNGPSLTEA LENAGIFYEA QYKEVKVVAN AYKTFANRVN NLKKKLDQLK STLPDPEESP VPSPSMDAPS PTGSESPFQG MGGEESQSPT MESEKSATPE PVTDNRDVED MELSDVEDDG SKIIVEDRKE KPAEKSAVST SVPTKPTENI SKASSCTPVP VTMTATPPLP KPVNTSLSPS PALALPNLAN VDLAKISSIL SSLTSVMKNT GVSPASRPSP GTPTSPSNLT SGLKTPAPAT TTSHNPLANI LSKVEITPES ILSALSKTQT QSAPALQGLS SLLQSVTGNP VPASEAASQS TSASPANTTV STIKGRNLPS SAQPFIPKSF NYSPNSSTSE VSSTSASKAS IGQSPGLPST TFKLPSNSLG FTATHNTSPA APPTEVTICQ SSEVSKPKLE SESTSPSLEM KIHNFLKGNP GFSGLNLNIP ILSSLGSSAP SESHPSDFQR GPTSTSIDNI DGTPVRDERS GTPTQDEMMD KPTSSSVDTM SLLSKIISPG SSTPSSTRSP PPGRDESYPR ELSNSVSTYR PFGLGSESPY KQPSDGMERP SSLMDSSQEK FYPDTSFQED EDYRDFEYSG PPPSAMMNLE KKPAKSILKS SKLSDTTEYQ PILSSYSHRA QEFGVKSAFP PSVRALLDSS ENCDRLSSSP GLFGAFSVRG NEPGSDRSPS PSKNDSFFTP DSNHNSLSQS TTGHLSLPQK QYPDSPHPVP HRSLFSPQNT LAAPTGHPPT SGVEKVLAST ISTTSTIEFK NMLKNASRKP SDDKHFGQAP SKGTPSDGVS LSNLTQPSLT ATDQQQQEEH YRIETRVSSS CLDLPDSTEE KGAPIETLGY HSASNRRMSG EPIQTVESIR VPGKGNRGHG REASRVGWFD LSTSGSSFDN GPSSASELAS LGGGGSGGLT GFKTAPYKER APQFQESVGS FRSNSFNSTF EHHLPPSPLE HGTPFQREPV GPSSAPPVPP KDHGGIFSRD APTHLPSVDL SNPFTKEAAL AHAAPPPPPG EHSGIPFPTP PPPPPPGEHS SSGGSGVPFS TPPPPPPPVD HSGVVPFPAP PLAEHGVAGA VAVFPKDHSS LLQGTLAEHF GVLPGPRDHG GPTQRDLNGP GLSRVRESLT LPSHSLEHLG PPHGGGGGGG SNSSSGPPLG PSHRDTISRS GIILRSPRPD FRPREPFLSR DPFHSLKRPR PPFARGPPFF APKRPFFPPR Y
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