PRAME family member 20 (PRAMEF20)

About PRAME family member 20

PRAME family member 20 (PRAMEF20) is a protein from Homo sapiens identified by UniProt accession Q5VT98, 475 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	PRAME family member 20
UniProt accession	Q5VT98
Gene	PRAMEF20
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VT98-F1	alphafold	PREDICTED	85.19	—

Amino-acid sequence (475 residues)

MSIRTPPRLL ELAGRSLLRD EALAISTLEE LPTELFPPLF MEAFSRRHCE ALKLMVQAWP FLRLPLGSLM KRPCPETFQA VLDGLDALLT HRVRLRRWKL QVLDLQDVSE NFWMVWSEAM ARRCLPNAMM NRKPLQDCPR MRGQQPLTVF IDLCLKNRTL DEYFTCLFLW VKQREGLVHL CCKKLKMLGM LFHNIRNILK TVNLDCIQEV EVNCNWTLPV LAEFTPYLGQ MRNLRKLVLS DIDSRYISPE QKKEFVTQFT TQFLKLRCLQ KLYMNSVSFL EGHLDQMLSC LKTSLNILAI TNCVLLESDL KHLSKYPSIG QLKTLDLSGT RLANFSLVPL QVLLEKVAAT LEYLDLDDCG IVDSQVNAIL PALSRCFELT TFSFRGNPIS TATLENLLCH TIRLNNLCLE LYPAPRESYD VRGIVCRSRF AQLGAELMGR VRALREPERI LFCTDYCPQC GNRSLYDLEV DRCCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards