Leucine-rich repeat-containing protein 38 (LRRC38)

About Leucine-rich repeat-containing protein 38

Leucine-rich repeat-containing protein 38 (LRRC38) is a protein from Homo sapiens identified by UniProt accession Q5VT99, 294 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 38
UniProt accession	Q5VT99
Gene	LRRC38
Organism	Homo sapiens
Length	294 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

diastolic blood pressure · score 0.29
Abnormality of refraction · score 0.28
neurodegenerative disease · score 0.27
body height · score 0.05
Familial exudative vitreoretinopathy · score 0.04
proliferative vitreoretinopathy · score 0.04
exudative vitreoretinopathy 2, X-linked · score 0.03
46,XX testicular disorder of sex development · score 0.03
46,XX ovotesticular disorder of sex development · score 0.03
46,XY complete gonadal dysgenesis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VT99-F1	alphafold	PREDICTED	86.11	—

Amino-acid sequence (294 residues)

MRPRAPACAA AALGLCSLLL LLAPGHACPA GCACTDPHTV DCRDRGLPSV PDPFPLDVRK LLVAGNRIQR IPEDFFIFYG DLVYLDFRNN SLRSLEEGTF SGSAKLVFLD LSYNNLTQLG AGAFRSAGRL VKLSLANNNL VGVHEDAFET LESLQVLELN DNNLRSLSVA ALAALPALRS LRLDGNPWLC DCDFAHLFSW IQENASKLPK GLDEIQCSLP MESRRISLRE LSEASFSECR FSLSLTDLCI IIFSGVAVSI AAIISSFFLA TVVQCLQRCA PNKDAEDEDE DKDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards