PRAME family member 17 (PRAMEF17)

About PRAME family member 17

PRAME family member 17 (PRAMEF17) is a protein from Homo sapiens identified by UniProt accession Q5VTA0, 474 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	PRAME family member 17
UniProt accession	Q5VTA0
Gene	PRAMEF17
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

genetic disorder · score 0.16
azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VTA0-F1	alphafold	PREDICTED	76.07	—

Amino-acid sequence (474 residues)

MSLQSPSRLL ELAGQSLLRN QFLTIFILDE LPREVFPLMF MEASSMRHFE ALKLMVQAWP FLRLPLGSLM KTPHLETLQA VLKGLDTLLA QKLRPRRWKL QVLDLRDVDG NFWTIWSGAR ALSCSPEAMS KRQTVEDYPR TGEHQPLKVF IDLCQKESTL DECLSYLCRW IHYRRGLVHL CCNKVQNYSM PTSSFRNLLK RVYPDSIQEL EIKRKCSLNK TGKFAPYLSQ MSNLRKLFLA FGYDDELYVS GQQQFVPDLD CPFLCLYYPQ MLYIRKISNI KEHLEHLLRC LKNPLGTFIF CHAYLADQDM ECLSQYPSLS QLKELHLIHI LMWTTNLEPL GALLEKVAAT LEILTLKDCQ IQDSQLRVLL PALSRCSQLT TFYFRGNETS TNALKDLLCH TGGLSKLGLE LYPAPLECLD NRGHVNWEIL APIRAELMCT LREVRQPKRI FFGPIPCPSC GSWPSEKVDF HLCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards