About Dynein axonemal intermediate chain 4
Dynein axonemal intermediate chain 4 (DNAI4) is a protein
from Homo sapiens identified by UniProt accession
Q5VTH9, 848 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Dynein axonemal intermediate chain 4 |
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| UniProt accession | Q5VTH9 |
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| Gene | DNAI4 |
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| Organism | Homo sapiens |
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| Length | 848 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (111)
Diseases linked to this target (Open Targets).
- lymphocyte percentage of leukocytes · score 0.28
- cystatin C measurement · score 0.27
- serum urea measurement · score 0.27
- creatinine measurement · score 0.27
- neutrophil percentage of leukocytes · score 0.25
- body height · score 0.24
- lymphocyte count · score 0.24
- blood urea nitrogen measurement · score 0.23
- platelet-to-lymphocyte ratio · score 0.23
- monocyte count · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VTH9-F1 | alphafold | PREDICTED | 67.78 | — |
Amino-acid sequence (848 residues)
MTPGKHSGAS ARAANGGAWG YRDFRGGQKK GWCTTPQLVA TMPVSPAGSH KQQNFGLNNA TQPKKSISFF ATMKATSVKG YTGANQSRMA VSKTVLIPPE LKTVEKPNPN IKTTQVFDIN GTDVTPRPLY HPDPLTGTAK PSKLLTSQEG SLGSEFISSY SLYQNTINPS TLGQFTRSVL GSSTVSKSSV SASESIAEDL EEPSYKRERL TSFTDLQVIR AAPEKIVTKE DLEKNIEIIL TETETLRFFD LPTVMVSVES EEAEKVTQRN KNYEVLCRNR LGNDLYVERM MQTFNGAPKN KDVQCDKIIM EDKGIMSTAW DLYDSYNAME LVSLSVKQSV VESSSKANVL PKDQDQRLPG STTEKNSETS SLMDIENVIL AKIHEDEEDH SDAILKSDKF HQDLFFMERV LMENIFQPKL AAYRQLPVLK EPEPEEPEDV LESAKHEEVE EESKKEEEEE IHAEESTIPA NLERLWSFSC DLTKGLNVSS LAWNKTNPDL LAVGYGHFGF KEQKRGLACC WSIKNPMWPE RIYQSPYGVT AVDFSIGAPN LLAVGYHNGT IAIYNVRSNS NVPVLDSSES PQKHLGPVWQ LQWIEQDRGT TGDGKREILV SISADGRISK WVIRKGLDCY DLMRLKRTTA ASNKKGGEKE KKDEALISRQ APGMCFAFHP KDTNIYLAGT EEGHIHKCSC SYNEQYLDTY RGHKGPVYKV TWNPFCHDVF LSCSADWGVI IWQQENVKPS LSFYPATSVV YDVAWSPKSS YIFAAANENR VEIWDLHIST LDPLIVNTAN PGIKFTTILF AKQTDCLLVG DSDGQVSVYE LRNMPTVLET GRGDIMDTLL GSKSNQSA
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