About Kelch domain-containing protein 7A
Kelch domain-containing protein 7A (KLHDC7A) is a protein
from Homo sapiens identified by UniProt accession
Q5VTJ3, 777 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Kelch domain-containing protein 7A |
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| UniProt accession | Q5VTJ3 |
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| Gene | KLHDC7A |
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| Organism | Homo sapiens |
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| Length | 777 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.44
- creatinine measurement · score 0.41
- breast carcinoma · score 0.35
- serum gamma-glutamyl transferase measurement · score 0.35
- cystatin C measurement · score 0.30
- low density lipoprotein cholesterol measurement · score 0.29
- gut microbiome measurement · score 0.10
- attention deficit-hyperactivity disorder 8 · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- schizophrenia 15 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VTJ3-F1 | alphafold | PREDICTED | 60.89 | — |
Amino-acid sequence (777 residues)
MFPRGAEAQD WHLDMQLTGK VVLSAAALLL VTVAYRLYKS RPAPAQRWGG NGQAEAKEEA EGSGQPAVQE ASPGVLLRGP RRRRSSKRAE APQGCSCENP RGPYVLVTGA TSTDRKPQRK GSGEERGGQG SDSEQVPPCC PSQETRTAVG SNPDPPHFPR LGSEPKSSPA GLIAAADGSC AGGEPSPWQD SKPREHPGLG QLEPPHCHYV APLQGSSDMN QSWVFTRVIG VSREEAGALE AASDVDLTLH QQEGAPNSSY TFSSIARVRM EEHFIQKAEG VEPRLKGKVY DYYVESTSQA IFQGRLAPRT AALTEVPSPR PPPGSLGTGA ASGGQAGDTK GAAERAASPQ TGPWPSTRGF SRKESLLQIA ENPELQLQPD GFRLPAPPCP DPGALPGLGR SSREPHVQPV AGTNFFHIPL TPASAPQVRL DLGNCYEVLT LAKRQNLEAL KEAAYKVMSE NYLQVLRSPD IYGCLSGAER ELILQRRLRG RQYLVVADVC PKEDSGGLCC YDDEQDVWRP LARMPPEAVS RGCAICSLFN YLFVVSGCQG PGHQPSSRVF CYNPLTGIWS EVCPLNQARP HCRLVALDGH LYAIGGECLN SVERYDPRLD RWDFAPPLPS DTFALAHTAT VRAKEIFVTG GSLRFLLFRF SAQEQRWWAG PTGGSKDRTA EMVAVNGFLY RFDLNRSLGI AVYRCSASTR LWYECATYRT PYPDAFQCAV VDNLIYCVGR RSTLCFLADS VSPRFVPKEL RSFPAPQGTL LPTVLTLPTP DLPQTRV
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