Pre-mRNA-splicing factor 38B (PRPF38B)

About Pre-mRNA-splicing factor 38B

Pre-mRNA-splicing factor 38B (PRPF38B) is a protein from Homo sapiens identified by UniProt accession Q5VTL8, 546 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Pre-mRNA-splicing factor 38B
UniProt accession	Q5VTL8
Gene	PRPF38B
Organism	Homo sapiens
Length	546 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
nasopharyngeal neoplasm · score 0.21
pathological myopia · score 0.11
Myopia · score 0.11
breast cancer · score 0.04
dilated cardiomyopathy 1I · score 0.03
neoplasm · score 0.02
acute quadriplegic myopathy · score 0.01
Invasive Breast Carcinoma · score 0.01
juvenile dermatomyositis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VTL8-F1	alphafold	PREDICTED	59.82	—

Amino-acid sequence (546 residues)

MANNSPALTG NSQPQHQAAA AAAQQQQQCG GGGATKPAVS GKQGNVLPLW GNEKTMNLNP MILTNILSSP YFKVQLYELK TYHEVVDEIY FKVTHVEPWE KGSRKTAGQT GMCGGVRGVG TGGIVSTAFC LLYKLFTLKL TRKQVMGLIT HTDSPYIRAL GFMYIRYTQP PTDLWDWFES FLDDEEDLDV KAGGGCVMTI GEMLRSFLTK LEWFSTLFPR IPVPVQKNID QQIKTRPRKI KKDGKEGAEE IDRHVERRRS RSPRRSLSPR RSPRRSRSRS HHREGHGSSS FDRELEREKE RQRLEREAKE REKERRRSRS IDRGLERRRS RSRERHRSRS RSRDRKGDRR DRDREREKEN ERGRRRDRDY DKERGNEREK ERERSRERSK EQRSRGEVEE KKHKEDKDDR RHRDDKRDSK KEKKHSRSRS RERKHRSRSR SRNAGKRSRS RSKEKSSKHK NESKEKSNKR SRSGSQGRTD SVEKSKKREH SPSKEKSRKR SRSKERSHKR DHSDSKDQSD KHDRRRSQSI EQESQEKQHK NKDETV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards