About Protein-cysteine N-palmitoyltransferase HHAT
Protein-cysteine N-palmitoyltransferase HHAT (HHAT) is a protein
from Homo sapiens identified by UniProt accession
Q5VTY9, 493 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Protein-cysteine N-palmitoyltransferase HHAT |
|---|
| UniProt accession | Q5VTY9 |
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| Gene | HHAT |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- chondrodysplasia-pseudohermaphroditism syndrome · score 0.66
- Chondrodysplasia - disorder of sex development · score 0.65
- heel bone mineral density · score 0.41
- 46,XY complete gonadal dysgenesis · score 0.37
- bone quantitative ultrasound measurement · score 0.34
- triglyceride measurement · score 0.32
- ulcerative colitis · score 0.32
- schizophrenia · score 0.31
- cortical thickness · score 0.28
- coronary artery disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VTY9-F1 | alphafold | PREDICTED | 92.94 | — |
Amino-acid sequence (493 residues)
MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KHRPWILMLY GMWACWCVLG TPGVAMVLLH TTISFCVAQF RSQLLTWLCS LLLLSTLRLQ GVEEVKRRWY KTENEYYLLQ FTLTVRCLYY TSFSLELCWQ QLPAASTSYS FPWMLAYVFY YPVLHNGPIL SFSEFIKQMQ QQEHDSLKAS LCVLALGLGR LLCWWWLAEL MAHLMYMHAI YSSIPLLETV SCWTLGGLAL AQVLFFYVKY LVLFGVPALL MRLDGLTPPA LPRCVSTMFS FTGMWRYFDV GLHNFLIRYV YIPVGGSQHG LLGTLFSTAM TFAFVSYWHG GYDYLWCWAA LNWLGVTVEN GVRRLVETPC IQDSLARYFS PQARRRFHAA LASCSTSMLI LSNLVFLGGN EVGKTYWNRI FIQGWPWVTL SVLGFLYCYS HVGIAWAQTY ATD
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