Divergent protein kinase domain 1B (DIPK1B)

About Divergent protein kinase domain 1B

Divergent protein kinase domain 1B (DIPK1B) is a protein from Homo sapiens identified by UniProt accession Q5VUD6, 431 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Divergent protein kinase domain 1B
UniProt accession	Q5VUD6
Gene	DIPK1B
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

body height · score 0.28
appendicular lean mass · score 0.26
wheezing · score 0.22
sitting height measurement · score 0.21
mean corpuscular hemoglobin · score 0.03
diastolic blood pressure · score 0.03
systolic blood pressure · score 0.03
neurofibrillary tangles measurement · score 0.02
reticulocyte measurement · score 0.02
Alzheimer disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VUD6-F1	alphafold	PREDICTED	83.18	—

Amino-acid sequence (431 residues)

MRRLRRLAHL VLFCPFSKRL QGRLPGLRVR CIFLAWLGVF AGSWLVYVHY SSYSERCRGH VCQVVICDQY RKGIISGSVC QDLCELHMVE WRTCLSVAPG QQVYSGLWRD KDVTIKCGIE ETLDSKARSD AAPRRELVLF DKPTRGTSIK EFREMTLSFL KANLGDLPSL PALVGQVLLM ADFNKDNRVS LAEAKSVWAL LQRNEFLLLL SLQEKEHASR LLGYCGDLYL TEGVPHGAWH AAALPPLLRP LLPPALQGAL QQWLGPAWPW RAKIAIGLLE FVEELFHGSY GTFYMCETTL ANVGYTATYD FKMADLQQVA PEATVRRFLQ GRRCEHSTDC TYGRDCRAPC DRLMRQCKGD LIQPNLAKVC ALLRGYLLPG APADLREELG TQLRTCTTLS GLASQVEAHH SLVLSHLKTL LWKKISNTKY S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards