About Scm-like with four MBT domains protein 2
Scm-like with four MBT domains protein 2 (SFMBT2) is a protein
from Homo sapiens identified by UniProt accession
Q5VUG0, 894 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Scm-like with four MBT domains protein 2 |
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| UniProt accession | Q5VUG0 |
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| Gene | SFMBT2 |
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| Organism | Homo sapiens |
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| Length | 894 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- body height · score 0.45
- metabolite measurement · score 0.32
- glucuronate measurement · score 0.30
- monocyte percentage of leukocytes · score 0.24
- PHF-tau measurement · score 0.23
- lean body mass · score 0.23
- neurodegenerative disease · score 0.23
- gut microbiome measurement · score 0.22
- taxonomic microbiome measurement · score 0.22
- whole body water mass · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VUG0-F1 | alphafold | PREDICTED | 75.88 | — |
Amino-acid sequence (894 residues)
MESTLSASNM QDPSSSPLEK CLGSANGNGD LDSEEGSSLE ETGFNWGEYL EETGASAAPH TSFKHVEISI QSNFQPGMKL EVANKNNPDT YWVATIITTC GQLLLLRYCG YGEDRRADFW CDVVIADLHP VGWCTQNNKV LMPPDAIKEK YTDWTEFLIR DLTGSRTAPA NLLEGPLRGK GPIDLITVGS LIELQDSQNP FQYWIVSVIE NVGGRLRLRY VGLEDTESYD QWLFYLDYRL RPVGWCQENK YRMDPPSEIY PLKMASEWKC TLEKSLIDAA KFPLPMEVFK DHADLRSHFF TVGMKLETVN MCEPFYISPA SVTKVFNNHF FQVTIDDLRP EPSKLSMLCH ADSLGILPVQ WCLKNGVSLT PPKGYSGQDF DWADYHKQHG AQEAPPFCFR NTSFSRGFTK NMKLEAVNPR NPGELCVASV VSVKGRLMWL HLEGLQTPVP EVIVDVESMD IFPVGWCEAN SYPLTAPHKT VSQKKRKIAV VQPEKQLPPT VPVKKIPHDL CLFPHLDTTG TVNGKYCCPQ LFINHRCFSG PYLNKGRIAE LPQSVGPGKC VLVLKEVLSM IINAAYKPGR VLRELQLVED PHWNFQEETL KAKYRGKTYR AVVKIVRTSD QVANFCRRVC AKLECCPNLF SPVLISENCP ENCSIHTKTK YTYYYGKRKK ISKPPIGESN PDSGHPKPAR RRKRRKSIFV QKKRRSSAVD FTAGSGEESE EEDADAMDDD TASEETGSEL RDDQTDTSSA EVPSARPRRA VTLRSGSEPV RRPPPERTRR GRGAPAASSA EEGEKCPPTK PEGTEDTKQE EEERLVLESN PLEWTVTDVV RFIKLTDCAP LAKIFQEQDI DGQALLLLTL PTVQECMELK LGPAIKLCHQ IERVKVAFYA QYAN
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