About Threonylcarbamoyladenosine tRNA methylthiotransferase
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) is a protein
from Homo sapiens identified by UniProt accession
Q5VV42, 579 residues long.
MolForge cross-references it against 0 known binders and
222 disease associations.
Target properties
| Protein name | Threonylcarbamoyladenosine tRNA methylthiotransferase |
|---|
| UniProt accession | Q5VV42 |
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| Gene | CDKAL1 |
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| Organism | Homo sapiens |
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| Length | 579 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (222)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.63
- diabetes mellitus · score 0.51
- mean corpuscular volume · score 0.49
- body mass index · score 0.48
- birth weight · score 0.48
- HbA1c measurement · score 0.47
- glucose measurement · score 0.47
- Crohn's disease · score 0.46
- sex hormone-binding globulin measurement · score 0.46
- psoriasis · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VV42-F1 | alphafold | PREDICTED | 82.37 | — |
Amino-acid sequence (579 residues)
MPSASCDTLL DDIEDIVSQE DSKPQDRHFV RKDVVPKVRR RNTQKYLQEE ENSPPSDSTI PGIQKIWIRT WGCSHNNSDG EYMAGQLAAY GYKITENASD ADLWLLNSCT VKNPAEDHFR NSIKKAQEEN KKIVLAGCVP QAQPRQDYLK GLSIIGVQQI DRVVEVVEET IKGHSVRLLG QKKDNGRRLG GARLDLPKIR KNPLIEIISI NTGCLNACTY CKTKHARGNL ASYPIDELVD RAKQSFQEGV CEIWLTSEDT GAYGRDIGTN LPTLLWKLVE VIPEGAMLRL GMTNPPYILE HLEEMAKILN HPRVYAFLHI PVQSASDSVL MEMKREYCVA DFKRVVDFLK EKVPGITIAT DIICGFPGET DQDFQETVKL VEEYKFPSLF INQFYPRPGT PAAKMEQVPA QVKKQRTKDL SRVFHSYSPY DHKIGERQQV LVTEESFDSK FYVAHNQFYE QVLVPKNPAF MGKMVEVDIY ESGKHFMKGQ PVSDAKVYTP SISKPLAKGE VSGLTKDFRN GLGNQLSSGS HTSAASQCDS ASSRMVLPMP RLHQDCALRM SVGLALLGLL FAFFVKVYN
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