BRO1 domain-containing protein BROX (BROX)

About BRO1 domain-containing protein BROX

BRO1 domain-containing protein BROX (BROX) is a protein from Homo sapiens identified by UniProt accession Q5VW32, 411 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	BRO1 domain-containing protein BROX
UniProt accession	Q5VW32
Gene	BROX
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

appendicular lean mass · score 0.26
coronary artery bypass · score 0.15
coronary artery disease · score 0.14
angina pectoris · score 0.09
cardiovascular disease · score 0.07
myocardial infarction · score 0.06
metabolite measurement · score 0.05
Vasodilators used in cardiac diseases use measurement · score 0.04
HMG CoA reductase inhibitor use measurement · score 0.04
aspirin use measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VW32-F1	alphafold	PREDICTED	92.04	—

Amino-acid sequence (411 residues)

MTHWFHRNPL KATAPVSFNY YGVVTGPSAS KICNDLRSSR ARLLELFTDL SCNPEMMKNA ADSYFSLLQG FINSLDESTQ ESKLRYIQNF KWTDTLQGQV PSAQQDAVFE LISMGFNVAL WYTKYASRLA GKENITEDEA KEVHRSLKIA AGIFKHLKES HLPKLITPAE KGRDLESRLI EAYVIQCQAE AQEVTIARAI ELKHAPGLIA ALAYETANFY QKADHTLSSL EPAYSAKWRK YLHLKMCFYT AYAYCYHGET LLASDKCGEA IRSLQEAEKL YAKAEALCKE YGETKGPGPT VKPSGHLFFR KLGNLVKNTL EKCQRENGFI YFQKIPTEAP QLELKANYGL VEPIPFEFPP TSVQWTPETL AAFDLTKRPK DDSTKPKPEE EVKPVKEPDI KPQKDTGCYI S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards