About Interleukin-23 receptor
Interleukin-23 receptor (IL23R) is a protein
from Homo sapiens identified by UniProt accession
Q5VWK5, 629 residues long.
MolForge cross-references it against 0 known binders and
317 disease associations.
Target properties
| Protein name | Interleukin-23 receptor |
|---|
| UniProt accession | Q5VWK5 |
|---|
| Gene | IL23R |
|---|
| Organism | Homo sapiens |
|---|
| Length | 629 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (317)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.47
- inflammatory bowel disease · score 0.46
- Crohn's disease · score 0.45
- chronic mucocutaneous candidiasis · score 0.37
- psoriasis · score 0.35
- ankylosing spondylitis · score 0.33
- rheumatoid arthritis · score 0.27
- sarcoidosis · score 0.27
- interleukin 23 receptor measurement · score 0.25
- celiac disease · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VWK5-F1 | alphafold | PREDICTED | 68.17 | — |
Amino-acid sequence (629 residues)
MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI YCQAAIKNCQ PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY CTAECPKHFQ ETLICGKDIS SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK LTYIDTKYVV HVKSLETEEE QQYLTSSYIN ISTDSLQGGK KYLVWVQAAN ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII YWDSQTTIEK VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN RGDIGLLLGM IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI PNMKNSNVVK MLQENSELMN NNSSEQVLYV DPMITEIKEI FIPEHKPTDY KKENTGPLET RDYPQNSLFD NTTVVYIPDL NTGYKPQISN FLPEGSHLSN NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL SNTIFLGELS LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI VNEELPSINT YFPQNILESH FNRISLLEK
Explore Interleukin-23 receptor with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets