PRAME family member 18 (PRAMEF18)

About PRAME family member 18

PRAME family member 18 (PRAMEF18) is a protein from Homo sapiens identified by UniProt accession Q5VWM3, 479 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 18
UniProt accession	Q5VWM3
Gene	PRAMEF18
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VWM3-F1	alphafold	PREDICTED	83.73	—

Amino-acid sequence (479 residues)

MSFQAPRRLL ELAGQSLLRD QALAISVLDE LPRELFPPLF VEAFTSRRCE VLKVMVQAWP FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRWKL QVLEMRDVDE NFWTIWSGAR LLSCSPEAMS KRQTVEDCPR TGEKQPLKVF MDVCLKEKFM DEDLSFFSGW VQHRRGSVHL CCTKVVNYSM SILNFRNILE TVYPDSIQVL EIWNMCWLCM IVEFSRYLSQ MRNLRKLFIS DGCRYLLSSD SQEQLVAEFS SVLLRLENLQ MLYVRRVCFF RGHLDQLIRC LRSPLETLAL TYGFLEEEDL KCLPRYPSLS QLKQLNLSHG ALRFIRLEPL RALLEKVAAT LQTLFLVDCG IGYSKLRVIL PALSRCSNLT TFCFHGNDTS MDALKDLLRH TGRLSNLSLE TYPAPRESLD NRGRVILELL TPLQAELMRI LREVREPKRI FFGPVSCPCC GTSPTEQLES NFCLWGRPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards