PRAME family member 8 (PRAMEF8)

About PRAME family member 8

PRAME family member 8 (PRAMEF8) is a protein from Homo sapiens identified by UniProt accession Q5VWM4, 474 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 8
UniProt accession	Q5VWM4
Gene	PRAMEF8
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VWM4-F1	alphafold	PREDICTED	86.58	—

Amino-acid sequence (474 residues)

MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE TLKTMVQAWP FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL QVLDLRNVDE NFCDIFSGAT ASFPEALSQK QTADNCPGTG RQQPFMVFID LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC KELQVFGMPI HSIIEVLNMV ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI RASACIPPDN KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL QTLDLEDCGI MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT VGLSKLSLEL YPAPLESYDT QGALCWGRFA ELGAELMNTL RDLRQPKIIV FCTVPCPRCG IRASYDLEPS HCLC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards