PRAME family member 13 (PRAMEF13)

About PRAME family member 13

PRAME family member 13 (PRAMEF13) is a protein from Homo sapiens identified by UniProt accession Q5VWM6, 474 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 13
UniProt accession	Q5VWM6
Gene	PRAMEF13
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VWM6-F1	alphafold	PREDICTED	82.12	—

Amino-acid sequence (474 residues)

MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF MEAFRRRHFQ TLTVMVQAWP FTCLPLGSLM KTLHLETLKA LLEGLHMLLT QKDRPRRRKL QVLDLRDVDE NFWARWPGAW ALSCFPETMS KRQTAEDRPR MGEHQPLKVF IDICLKEIPQ DECLRYLFQW VYQRRGLVHL CCSKLVNYLT PIKHLRKSLK IIYLNSIQEL EIHNMSWPRL IRKLRCYLKE MKTLGKLVFS RCHHSTSDNE LEGRLVTKFS SVFLGLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL TYGYLLEEDV KCLSQYPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS LETLILEGCQ IHYSQLSAIL PGLSRCSQLT TFYFGRNCMS MGALKDLLRH TSGLSKLSLE TYPAPEESLN SLVRVNWEIF TPLRAELMCT LREVRQPKRI FIGPTPCPSC GSSLSEELEL HLCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards