About CUB domain-containing protein 2
CUB domain-containing protein 2 (CDCP2) is a protein
from Homo sapiens identified by UniProt accession
Q5VXM1, 540 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | CUB domain-containing protein 2 |
|---|
| UniProt accession | Q5VXM1 |
|---|
| Gene | CDCP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 540 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.20
- platelet count · score 0.19
- Testicular regression syndrome · score 0.04
- 46,XX ovotesticular disorder of sex development · score 0.04
- 46,XY complete gonadal dysgenesis · score 0.03
- testicular agenesis · score 0.03
- 46,XY sex reversal 3 · score 0.03
- lean body mass · score 0.03
- body mass index · score 0.03
- diet measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VXM1-F1 | alphafold | PREDICTED | 81.81 | — |
Amino-acid sequence (540 residues)
MLAEWGACLL LAVALLGPGL QAQAMEGVKC GGVLSAPSGN FSSPNFPRLY PYNTECSWLI VVAEGSSVLL TFHAFDLEYH DTCSFDFLEI YNGASPDKGN LLGRFCGKVP PPPFTSSWHV MSVIFHSDKH VASHGFSAGY QKDVCGGVLT GLSGVLTSPE YPNNYPNSME CHWVIRAAGP AHVKLVFVDF QVEGNEECTY DYVAVLGGPG PTRGHHYCGS TRPPTLVSLG HELQVVFKSD FNIGGRGFKA YYFSGECQEV YMAMRGNFSS PQYPSSYPNN IRCHWTIRLP PGYQVKVFFL DLDLEEPNSL TKTCDFDHLA AFDGASEEAP LLGNWCGHHL PPPVTSSHNQ LLLLLHTDRS TTRRGFSVAY IGVVPMNVSC SRTDFQILIS TQALAPLERT KVYLGSRSCA AQEVGGNLRI QARFDTCGTE SQRRNNTSVI VSVLYIDFSA AGREDIHEYE VRCEPRRKEA SVHLLSGSHW LGPYAATAEH LQEAPPMDEA EALEGPVSMV AQDTSDIVFL GLCILAGILM VIAIVVLMLL
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