Forkhead box protein B2 (FOXB2)

About Forkhead box protein B2

Forkhead box protein B2 (FOXB2) is a protein from Homo sapiens identified by UniProt accession Q5VYV0, 432 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Forkhead box protein B2
UniProt accession	Q5VYV0
Gene	FOXB2
Organism	Homo sapiens
Length	432 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

response to darapladib · score 0.16
Diarrhea · score 0.16
metabolite measurement · score 0.04
hemoglobin measurement · score 0.03
cancer · score 0.03
mean corpuscular hemoglobin concentration · score 0.02
neoplasm · score 0.02
hemoglobin A1 measurement · score 0.02
Red cell distribution width · score 0.02
hepatocellular carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VYV0-F1	alphafold	PREDICTED	59.15	—

Amino-acid sequence (432 residues)

MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY REHTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG SFLRRRKRFK VLRADHTHLH AGSTKSAPGA GPGGHLHPHH HHHPHHHHHH HAAAHHHHHH HPPQPPPPPP PPPPHMVHYF HQQPPTAPQP PPHLPSQPPQ QPPQQSQPQQ PSHPGKMQEA AAVAAAAAAA AAAAVGSVGR LSQFPPYGLG SAAAAAAAAA ASTSGFKHPF AIENIIGRDY KGVLQAGGLP LASVMHHLGY PVPGQLGNVV SSVWPHVGVM DSVAAAAAAA AAAGVPVGPE YGAFGVPVKS LCHSASQSLP AMPVPIKPTP ALPPVSALQP GLTVPAASQQ PPAPSTVCSA AAASPVASLL EPTAPTSAES KGGSLHSVLV HS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards