About Terminal nucleotidyltransferase 4A
Terminal nucleotidyltransferase 4A (TENT4A) is a protein
from Homo sapiens identified by UniProt accession
Q5XG87, 792 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Terminal nucleotidyltransferase 4A |
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| UniProt accession | Q5XG87 |
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| Gene | TENT4A |
|---|
| Organism | Homo sapiens |
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| Length | 792 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- cancer · score 0.54
- age at menopause · score 0.40
- body height · score 0.38
- eosinophil count · score 0.30
- sphingolipid measurement · score 0.30
- body weight · score 0.27
- multiple sclerosis · score 0.27
- protein measurement · score 0.25
- HbA1c measurement · score 0.20
- lean body mass · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5XG87-F1 | alphafold | PREDICTED | 60.71 | — |
Amino-acid sequence (792 residues)
MDPRVAWIQP EQKGPANALW MQIWETSQGV GRGGSGFASY FCLNSPALDT AAAAGAAGRG SGGLGPALPA ASPPPPGPTA PAALPPALLT ALGPAAEGAR RLHKSPSLSS SSSSSSSNAE SGTESPGCSS SSSSSASLGR PGGGRGGAFF NFADGAPSAP GTANGHPGPR GPAPAGSPSQ HQFHPGRRKR ENKASTYGLN YLLSGSRAAA LSGGGGPGAQ APRPGTPWKS RAYSPGIQGL HEEIIDFYNF MSPCPEEAAM RREVVKRIET VVKDLWPTAD VQIFGSFSTG LYLPTSDIDL VVFGKWERPP LQLLEQALRK HNVAEPCSIK VLDKATVPII KLTDQETEVK VDISFNMETG VRAAEFIKNY MKKYSLLPYL ILVLKQFLLQ RDLNEVFTGG ISSYSLILMA ISFLQLHPRI DARRADENLG MLLVEFFELY GRNFNYLKTG IRIKEGGAYI AKEEIMKAMT SGYRPSMLCI EDPLLPGNDV GRSSYGAMQV KQVFDYAYIV LSHAVSPLAR SYPNRDAEST LGRIIKVTQE VIDYRRWIKE KWGSKAHPSP GMDSRIKIKE RIATCNGEQT QNREPESPYG QRLTLSLSSP QLLSSGSSAS SVSSLSGSDV DSDTPPCTTP SVYQFSLQAP APLMAGLPTA LPMPSGKPQP TTSRTLIMTT NNQTRFTIPP PTLGVAPVPC RQAGVEGTAS LKAVHHMSSP AIPSASPNPL SSPHLYHKQH NGMKLSMKGS HGHTQGGGYS SVGSGGVRPP VGNRGHHQYN RTGWRRKKHT HTRDSLPVSL SR
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