About Carboxylesterase 4A
Carboxylesterase 4A (CES4A) is a protein
from Homo sapiens identified by UniProt accession
Q5XG92, 561 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Carboxylesterase 4A |
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| UniProt accession | Q5XG92 |
|---|
| Gene | CES4A |
|---|
| Organism | Homo sapiens |
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| Length | 561 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.09
- hemoglobin measurement · score 0.08
- erythrocyte count · score 0.07
- adolescent idiopathic scoliosis · score 0.07
- bone quantitative ultrasound measurement · score 0.06
- apolipoprotein A 1 measurement · score 0.05
- high density lipoprotein cholesterol measurement · score 0.04
- myeloid white cell count · score 0.04
- mean corpuscular hemoglobin concentration · score 0.03
- monocyte count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5XG92-F1 | alphafold | PREDICTED | 92.75 | — |
Amino-acid sequence (561 residues)
MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE KKMAFWMSLY QSQRPEKQRQ F
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