About Zinc finger protein with KRAB and SCAN domains 2
Zinc finger protein with KRAB and SCAN domains 2 (ZKSCAN2) is a protein
from Homo sapiens identified by UniProt accession
Q63HK3, 967 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Zinc finger protein with KRAB and SCAN domains 2 |
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| UniProt accession | Q63HK3 |
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| Gene | ZKSCAN2 |
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| Organism | Homo sapiens |
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| Length | 967 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.37
- attention deficit hyperactivity disorder · score 0.29
- substance abuse · score 0.29
- antisocial behaviour measurement · score 0.29
- risk-taking behaviour · score 0.27
- smoking initiation · score 0.25
- smoking behavior · score 0.24
- alcohol consumption measurement · score 0.13
- metabolite measurement · score 0.08
- PHF-tau measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q63HK3-F1 | alphafold | PREDICTED | 50.41 | — |
Amino-acid sequence (967 residues)
MAVALDSQID APLEVEGCLI MKVEKDPEWA SEPILEGSDS SETFRKCFRQ FCYEDVTGPH EAFSKLWELC CRWLKPEMRS KEQILELLVI EQFLTILPEK IQAWAQKQCP QSGEEAVALV VHLEKETGRL RQQVSSPVHR EKHSPLGAAW EVADFQPEQV ETQPRAVSRE EPGSLHSGHQ EQLNRKRERR PLPKNARPSP WVPALADEWN TLDQEVTTTR LPAGSQEPVK DVHVARGFSY RKSVHQIPAQ RDLYRDFRKE NVGNVVSLGS AVSTSNKITR LEQRKEPWTL GLHSSNKRSI LRSNYVKEKS VHAIQVPARS AGKTWREQQQ WGLEDEKIAG VHWSYEETKT FLAILKESRF YETLQACPRN SQVYGAVAEW LRECGFLRTP EQCRTKFKSL QKSYRKVRNG HMLEPCAFFE DMDALLNPAA RAPSTDKPKE MIPVPRLKRI AISAKEHISL VEEEEAAEDS DDDEIGIEFI RKSEIHGAPV LFQNLSGVHW GYEETKTFLD ILRETRFYEA LQACHRKSKL YGAVAEQLRE CGFLRTPEQC RTKFKSLQKS YRKVKNGHVL ESCAFYKEMD ALINSRASAP SPSTPEEVPS PSRQERGGIE VEPQEPTGWE PEETSQEAVI EDSCSERMSE EEIVQEPEFQ GPPGLLQSPN DFEIGSSIKE DPTQIVYKDM EQHRALIEKS KRVVSQSTDP SKYRKRECIS GRQWENLQGI RQGKPMSQPR DLGKAVVHQR PFVGKRPYRL LKYGESFGRS TRLMCRMTHH KENPYKCGVC GKCFGRSRSL IRHQRIHTGE KPFKCLDCGK SFNDSSNFGA HQRIHTGEKP YRCGECGKCF SQSSSLIIHQ RTHTGEKPYQ CGECGKSFTN SSHFSAHRRV HTGENPYKCV DCEKSFNNCT RFREHRRIHT GEKPYGCAQC GKRFSKSSVL TKHREVHVRE KPLPHPPSLY CPENPHKGKT DEFRKTF
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