Kynurenine formamidase (AFMID)

About Kynurenine formamidase

Kynurenine formamidase (AFMID) is a protein from Homo sapiens identified by UniProt accession Q63HM1, 303 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.

Target properties

Protein name	Kynurenine formamidase
UniProt accession	Q63HM1
Gene	AFMID
Organism	Homo sapiens
Length	303 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (129)

Diseases linked to this target (Open Targets).

serum metabolite measurement · score 0.30
protein measurement · score 0.28
erythrocyte count · score 0.27
mean corpuscular volume · score 0.27
Red cell distribution width · score 0.26
urinary metabolite measurement · score 0.24
reticulocyte count · score 0.22
mean reticulocyte volume · score 0.21
mean corpuscular hemoglobin concentration · score 0.20
mean corpuscular hemoglobin · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q63HM1-F1	alphafold	PREDICTED	94.03	—

Amino-acid sequence (303 residues)

MMDVSGVGFP SKVPWKKMSA EELENQYCPS RWVVRLGAEE ALRTYSQIGI EATTRARATR KSLLHVPYGD GEGEKVDIYF PDESSEALPF FLFFHGGYWQ SGSKDESAFM VHPLTAQGVA VVIVAYGIAP KGTLDHMVDQ VTRSVAFVQK RYPSNKGIYL CGHSAGAHLA AMMLLADWTK HGVTPNLRGF FLVSGVFDLE PIVYTSQNVA LQLTLEDAQR NSPQLKVAQA QPVDPTCRVL VVVGQFDSPE FHRQSWEFYQ TLCQGEWKAS FEELHDVDHF EIVENLTQKD NVLTQIILKT IFQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards