Pecanex-like protein 4 (PCNX4)

About Pecanex-like protein 4

Pecanex-like protein 4 (PCNX4) is a protein from Homo sapiens identified by UniProt accession Q63HM2, 1172 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Pecanex-like protein 4
UniProt accession	Q63HM2
Gene	PCNX4
Organism	Homo sapiens
Length	1172 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

calcium measurement · score 0.30
donor genotype effect measurement · score 0.18
response to allogeneic hematopoietic stem cell transplant · score 0.18
mortality · score 0.18
mean platelet volume · score 0.18
age-related hearing impairment · score 0.13
benign adult familial myoclonic epilepsy · score 0.06
deafness · score 0.06
Autosomal recessive spastic paraplegia type 27 · score 0.04
Autosomal recessive spastic paraplegia type 44 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q63HM2-F1	alphafold	PREDICTED	78.17	—

Amino-acid sequence (1172 residues)

MSPDVPLLND YKQDFFLKRF PQTVLGGPRF KLGYCAPPYI YVNQIILFLM PWVWGGVGTL LYQLGILKDY YTAALSGGLM LFTAFVIQFT SLYAKNKSTT VERILTTDIL AEEDEHEFTS CTGAETVKFL IPGKKYVANT VFHSILAGLA CGLGTWYLLP NRITLLYGST GGTALLFFFG WMTLCIAEYS LIVNTATETA TFQTQDTYEI IPLMRPLYIF FFVSVDLAHR FVVNMPALEH MNQILHILFV FLPFLWALGT LPPPDALLLW AMEQVLEFGL GGSSMSTHLR LLVMFIMSAG TAIASYFIPS TVGVVLFMTG FGFLLSLNLS DMGHKIGTKS KDLPSGPEKH FSWKECLFYI IILVLALLET SLLHHFAGFS QISKSNSQAI VGYGLMILLI ILWILREIQS VYIIGIFRNP FYPKDVQTVT VFFEKQTRLM KIGIVRRILL TLVSPFAMIA FLSLDSSLQG LHSVSVCIGF TRAFRMVWQN TENALLETVI VSTVHLISST DIWWNRSLDT GLRLLLVGII RDRLIQFISK LQFAVTVLLT SWTEKKQRRK TTATLCILNI VFSPFVLVII VFSTLLSSPL LPLFTLPVFL VGFPRPIQSW PGAAGTTACV CADTVYYYQM VPRLTAVLQT AMAAGSLGLL LPGSHYLGRF QDRLMWIMIL ECGYTYCSIN IKGLELQETS CHTAEARRVD EVFEDAFEQE YTRVCSLNEH FGNVLTPCTV LPVKLYSDAR NVLSGIIDSH ENLKEFKGDL IKVLVWILVQ YCSKRPGMKE NVHNTENKGK APLMLPALNT LPPPKSPEDI DSLNSETFND WSDDNIFDDE PTIKKVIEEK HQLKDLPGTN LFIPGSVESQ RVGDHSTGTV PENDLYKAVL LGYPAVDKGK QEDMPYIPLM EFSCSHSHLV CLPAEWRTSC MPSSKMKEMS SLFPEDWYQF VLRQLECYHS EEKASNVLEE IAKDKVLKDF YVHTVMTCYF SLFGIDNMAP SPGHILRVYG GVLPWSVALD WLTEKPELFQ LALKAFRYTL KLMIDKASLG PIEDFRELIK YLEEYERDWY IGLVSDEKWK EAILQEKPYL FSLGYDSNMG IYTGRVLSLQ ELLIQVGKLN PEAVRGQWAN LSWELLYATN DDEERYSIQA HPLLLRNLTV QAAEPPLGYP IYSSKPLHIH LY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards