PI-PLC X domain-containing protein 3 (PLCXD3)

About PI-PLC X domain-containing protein 3

PI-PLC X domain-containing protein 3 (PLCXD3) is a protein from Homo sapiens identified by UniProt accession Q63HM9, 321 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	PI-PLC X domain-containing protein 3
UniProt accession	Q63HM9
Gene	PLCXD3
Organism	Homo sapiens
Length	321 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

IGF-1 measurement · score 0.33
complement component C7 measurement · score 0.05
breast carcinoma · score 0.04
hepatocellular carcinoma · score 0.04
gastric carcinoma · score 0.04
glioblastoma multiforme · score 0.03
atypical teratoid rhabdoid tumor · score 0.03
non-alcoholic fatty liver disease · score 0.03
clear cell renal carcinoma · score 0.03
metabolic syndrome · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q63HM9-F1	alphafold	PREDICTED	88.89	—

Amino-acid sequence (321 residues)

MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV GPEQPETVQN FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS TKPRDPDNEL YFAHGLFSAK VNEGLEEINA FLTDHHKEVV FLDFNHFYGM QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS LKYLWEKDYQ VLVFYHSPVA LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG SFFISQVVLT PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL GDFISTVIKL NYVFDEGEAN T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards