About Lysophospholipid acyltransferase LPCAT4
Lysophospholipid acyltransferase LPCAT4 (LPCAT4) is a protein
from Homo sapiens identified by UniProt accession
Q643R3, 524 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Lysophospholipid acyltransferase LPCAT4 |
|---|
| UniProt accession | Q643R3 |
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| Gene | LPCAT4 |
|---|
| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.32
- alcohol consumption measurement · score 0.18
- intelligence · score 0.18
- schizophrenia · score 0.18
- breast adenocarcinoma · score 0.18
- mean platelet volume · score 0.12
- glioblastoma multiforme · score 0.02
- ependymoma · score 0.02
- astrocytoma · score 0.02
- medulloblastoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q643R3-F1 | alphafold | PREDICTED | 82.90 | — |
Amino-acid sequence (524 residues)
MSQGSPGDWA PLDPTPGPPA SPNPFVHELH LSRLQRVKFC LLGALLAPIR VLLAFIVLFL LWPFAWLQVA GLSEEQLQEP ITGWRKTVCH NGVLGLSRLL FFLLGFLRIR VRGQRASRLQ APVLVAAPHS TFFDPIVLLP CDLPKVVSRA ENLSVPVIGA LLRFNQAILV SRHDPASRRR VVEEVRRRAT SGGKWPQVLF FPEGTCSNKK ALLKFKPGAF IAGVPVQPVL IRYPNSLDTT SWAWRGPGVL KVLWLTASQP CSIVDVEFLP VYHPSPEESR DPTLYANNVQ RVMAQALGIP ATECEFVGSL PVIVVGRLKV ALEPQLWELG KVLRKAGLSA GYVDAGAEPG RSRMISQEEF ARQLQLSDPQ TVAGAFGYFQ QDTKGLVDFR DVALALAALD GGRSLEELTR LAFELFAEEQ AEGPNRLLYK DGFSTILHLL LGSPHPAATA LHAELCQAGS SQGLSLCQFQ NFSLHDPLYG KLFSTYLRPP HTSRGTSQTP NASSPGNPTA LANGTVQAPK QKGD
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