About WD repeat-containing protein 25
WD repeat-containing protein 25 (WDR25) is a protein
from Homo sapiens identified by UniProt accession
Q64LD2, 544 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | WD repeat-containing protein 25 |
|---|
| UniProt accession | Q64LD2 |
|---|
| Gene | WDR25 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 544 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.45
- sex hormone-binding globulin measurement · score 0.39
- neurodegenerative disease · score 0.38
- gait measurement · score 0.24
- testosterone measurement · score 0.18
- glucose measurement · score 0.16
- chronotype measurement · score 0.16
- high density lipoprotein cholesterol measurement · score 0.13
- fasting blood glucose measurement · score 0.13
- blood protein measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q64LD2-F1 | alphafold | PREDICTED | 68.10 | — |
Amino-acid sequence (544 residues)
MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF ASGTLDVPKA GAQPTKHGSC EDPGGYRLPL AQLGRSDWGS CPSQRLQWPG KEPQVTFPIK EPSCSSLWTS HVPASHMPLA AARFKQVKLS RNFPKSSFHA QSESETVGKN GSSFQKKKCE DCVVPYTPRR LRQRQALSTE TGKGKDVEPQ GPPAGRAPAP LYVGPGVSEF IQPYLNSHYK ETTVPRKVLF HLRGHRGPVN TIQWCPVLSK SHMLLSTSMD KTFKVWNAVD SGHCLQTYSL HTEAVRAARW APCGRRILSG GFDFALHLTD LETGTQLFSG RSDFRITTLK FHPKDHNIFL CGGFSSEMKA WDIRTGKVMR SYKATIQQTL DILFLREGSE FLSSTDASTR DSADRTIIAW DFRTSAKISN QIFHERFTCP SLALHPREPV FLAQTNGNYL ALFSTVWPYR MSRRRRYEGH KVEGYSVGCE CSPGGDLLVT GSADGRVLMY SFRTASRACT LQGHTQACVG TTYHPVLPSV LATCSWGGDM KIWH
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