About Sialate:O-sulfotransferase 1
Sialate:O-sulfotransferase 1 (WSCD1) is a protein
from Homo sapiens identified by UniProt accession
Q658N2, 575 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Sialate:O-sulfotransferase 1 |
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| UniProt accession | Q658N2 |
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| Gene | WSCD1 |
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| Organism | Homo sapiens |
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| Length | 575 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- age at menarche · score 0.36
- diastolic blood pressure · score 0.21
- smoking status measurement · score 0.21
- C-reactive protein measurement · score 0.21
- Ataxia-telangiectasia · score 0.03
- astrocytoma · score 0.02
- stressful life event measurement · score 0.02
- colorectal cancer · score 0.02
- ulcerative colitis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q658N2-F1 | alphafold | PREDICTED | 77.42 | — |
Amino-acid sequence (575 residues)
MAKPFFRLQK FLRRTQFLLF FLTAAYLMTG SLLLLQRVRV ALPQGPRAPG PLQTLPVAAV ALGVGLLDSR ALHDPRVSPE LLLGVDMLQS PLTRPRPGPR WLRSRNSELR QLRRRWFHHF MSDSQGPPAL GPEAARPAIH SRGTYIGCFS DDGHERTLKG AVFYDLRKMT VSHCQDACAE RSYVYAGLEA GAECYCGNRL PAVSVGLEEC NHECKGEKGS VCGAVDRLSV YRVDELQPGS RKRRTATYRG CFRLPENITH AFPSSLIQAN VTVGTCSGFC SQKEFPLAIL RGWECYCAYP TPRFNLRDAM DSSVCGQDPE AQRLAEYCEV YQTPVQDTRC TDRRFLPNKS KVFVALSSFP GAGNTWARHL IEHATGFYTG SYYFDGTLYN KGFKGEKDHW RSRRTICVKT HESGRREIEM FDSAILLIRN PYRSLVAEFN RKCAGHLGYA ADRNWKSKEW PDFVNSYASW WSSHVLDWLK YGKRLLVVHY EELRRSLVPT LREMVAFLNV SVSEERLLCV ENNKEGSFRR RGRRSHDPEP FTPEMKDLIN GYIRTVDQAL RDHNWTGLPR EYVPR
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