About La-related protein 1B
La-related protein 1B (LARP1B) is a protein
from Homo sapiens identified by UniProt accession
Q659C4, 914 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | La-related protein 1B |
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| UniProt accession | Q659C4 |
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| Gene | LARP1B |
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| Organism | Homo sapiens |
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| Length | 914 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- mean corpuscular volume · score 0.37
- sex hormone-binding globulin measurement · score 0.36
- alkaline phosphatase measurement · score 0.36
- serum albumin measurement · score 0.34
- mean corpuscular hemoglobin concentration · score 0.28
- mean corpuscular hemoglobin · score 0.28
- IGF-1 measurement · score 0.28
- insulin like growth factor measurement · score 0.23
- type 2 diabetes mellitus · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q659C4-F1 | alphafold | PREDICTED | 55.88 | — |
Amino-acid sequence (914 residues)
MENWPTPSEL VNTGFQSVLS QGNKKPQNRK EKEEKVEKRS NSDSKENRET KLNGPGENVS EDEAQSSNQR KRANKHKWVP LHLDVVRSES QERPGSRNSS RCQPEANKPT HNNRRNDTRS WKRDREKRDD QDDVSSVRSE GGNIRGSFRG RGRGRGRGRG RGRGNPRLNF DYSYGYQEHG ERTDQPFQTE LNTSMMYYYD DGTGVQVYPV EEALLKEYIK RQIEYYFSVE NLERDFFLRG KMDEQGFLPI SLIAGFQRVQ ALTTNLNLIL EALKDSTEVE IVDEKMRKKI EPEKWPIPGP PPRSVPPTDF SQLIDCPEFV PGQAFCSHTE SAPNSPRIGS PLSPKKNSET SILQAMSRGL STSLPDLDSE PWIEVKKRHQ PAPVKLRESV SVPEGSLNQL CSSEEPEQEE LDFLFDEEIE QIGRKNTFTD WSDNDSDYEI DDQDLNKILI VTQTPPYVKK HPGGDRTGTH MSRAKITSEL AKVINDGLYY YEQDLWMEED ENKHTAIKQE VENFKKLNLI SKEQFENLTP ELPFEPNQEV PVAPSQSRQG GVQGVLHIPK KDLTDELAQK LFDVSEITSA AMVHSLPTAV PESPRIHPTR TPKTPRTPRL QDPNKTPRFY PVVKEPKAID VKSPRKRKTR HSTNPPLECH VGWVMDSRDR GPGTSSVSTS NASPSEGAPL AGSYGCTPHS FPKFQHPSHE LLKENGFTQQ VYHKYRRRCL SERKRLGIGQ SQEMNTLFRF WSFFLRDHFN KKMYEEFRQL AWEDAKENYR YGLECLFRFY SYGLEKKFRR EIFQDFQEET KKDYESGQLY GLEKFWAYLK YSQSKTQSID PKLQEYLCSF KRLEDFRVDP PISDEFGRKR HSSTSGEESN RHRLPPNSST KPPNAAKPTS TSELQVPINS PRRNISPESS DNSH
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