About Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PPP2R2D) is a protein
from Homo sapiens identified by UniProt accession
Q66LE6, 453 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform |
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| UniProt accession | Q66LE6 |
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| Gene | PPP2R2D |
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| Organism | Homo sapiens |
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| Length | 453 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.35
- self reported educational attainment · score 0.34
- body height · score 0.33
- mathematical ability · score 0.31
- intelligence · score 0.30
- neutrophil count · score 0.30
- systolic blood pressure · score 0.29
- C-reactive protein measurement · score 0.26
- chronotype measurement · score 0.23
- cognitive function measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q66LE6-F1 | alphafold | PREDICTED | 91.14 | — |
Amino-acid sequence (453 residues)
MAGAGGGGCP AGGNDFQWCF SQVKGAIDED VAEADIISTV EFNYSGDLLA TGDKGGRVVI FQREQENKSR PHSRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAHFLLST NDKTIKLWKI SERDKRAEGY NLKDEDGRLR DPFRITALRV PILKPMDLMV EASPRRIFAN AHTYHINSIS VNSDHETYLS ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF HPHQCNVFVY SSSKGTIRLC DMRSSALCDR HSKFFEEPED PSSRSFFSEI ISSISDVKFS HSGRYMMTRD YLSVKVWDLN MESRPVETHQ VHEYLRSKLC SLYENDCIFD KFECCWNGSD SAIMTGSYNN FFRMFDRDTR RDVTLEASRE SSKPRASLKP RKVCTGGKRR KDEISVDSLD FNKKILHTAW HPVDNVIAVA ATNNLYIFQD KIN
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