About Autophagy-related protein 16-1
Autophagy-related protein 16-1 (ATG16L1) is a protein
from Homo sapiens identified by UniProt accession
Q676U5, 607 residues long.
MolForge cross-references it against 0 known binders and
242 disease associations.
Target properties
| Protein name | Autophagy-related protein 16-1 |
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| UniProt accession | Q676U5 |
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| Gene | ATG16L1 |
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| Organism | Homo sapiens |
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| Length | 607 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (242)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- inflammatory bowel disease · score 0.44
- bilirubin measurement · score 0.35
- Crohn's disease · score 0.34
- ulcerative colitis · score 0.29
- alkaline phosphatase measurement · score 0.27
- visual perception measurement · score 0.25
- psoriasis · score 0.25
- ankylosing spondylitis · score 0.24
- Immature Reticulocyte Fraction Measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q676U5-F1 | alphafold | PREDICTED | 83.88 | — |
Amino-acid sequence (607 residues)
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK AVLWAQY
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