About Rap1 GTPase-activating protein 2
Rap1 GTPase-activating protein 2 (RAP1GAP2) is a protein
from Homo sapiens identified by UniProt accession
Q684P5, 730 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Rap1 GTPase-activating protein 2 |
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| UniProt accession | Q684P5 |
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| Gene | RAP1GAP2 |
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| Organism | Homo sapiens |
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| Length | 730 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.49
- leukocyte count · score 0.46
- lymphocyte percentage of leukocytes · score 0.42
- tonsillectomy risk measurement · score 0.36
- myeloid white cell count · score 0.36
- eosinophil count · score 0.35
- neutrophil percentage of leukocytes · score 0.33
- neutrophil-to-lymphocyte ratio · score 0.32
- platelet-to-lymphocyte ratio · score 0.31
- viral load · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q684P5-F1 | alphafold | PREDICTED | 64.87 | — |
Amino-acid sequence (730 residues)
MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA PPTMKSSEFF EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP YPQVILPQFG GYWIEDPENV GTPTSLGSSI CEEEEEDNLS PNTFGYKLEC KGEARAYRRH FLGKDHLNFY CTGSSLGNLI LSVKCEEAEG IEYLRVILRS KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLRFNPVL YPKASQMIVS YDEHEVNNTF KFGVIYQKAR QTLEEELFGN NEESPAFKEF LDLLGDTITL QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTDGDAQQLQ RKRHIGNDIV AIIFQEENTP FVPDMIASNF LHAYIVVQVE TPGTETPSYK VSVTAREDVP TFGPPLPSPP VFQKGPEFRE FLLTKLTNAE NACCKSDKFA KLEDRTRAAL LDNLHDELHA HTQAMLGLGP EEDKFENGGH GGFLESFKRA IRVRSHSMET MVGGQKKSHS GGIPGSLSGG ISHNSMEVTK TTFSPPVVAA TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RARCDSTSST PKTPDGGHSS QEIKSETSSN PSSPEICPNK EKPFMKLKEN GRAISRSSSS TSSVSSTAGE GEAMEEGDSG GSQPSTTSPF KQEVFVYSPS PSSESPSLGA AATPIIMSRS PTDAKSRNSP RSNLKFRFDK LSHASSGAGH
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